Disease-specific survival for patients with multiple myeloma: Significant improvements over time in all age groups

Edward Libby, David Garcia, Dulcinea Quintana, M. Houman Fekrazad, Julie Bauman, Ala Ebaid, Robert Hromas, Ian Rabinowitz, Charles Wiggins

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

This study analyzed the survival of patients with multiple myeloma. Surveillance, Epidemiology, and End Results (SEER) and Centers for Disease Control and Prevention (CDC) databases were queried to calculate myeloma cause-specific survival curves by the Kaplan and Meier product-limit method. The Cox proportional hazards model was used to assess univariate and multivariate predictors of myeloma cause-specific survival. The outcome of interest was death due to myeloma. Results from a Cox proportional hazards model restricted to age and time period at diagnosis demonstrated that the magnitude of improvement in survival by time period varied by age at diagnosis. Among patients under 60 years at diagnosis, hazard ratios for myeloma cause-specific death decreased by more 50% from the first interval of observation to the last. Hazard ratios decreased during the study period by 39% among patients 60-69 years of age and by 27% among patients who were 70 years of age and older. Survival is improving in patients with myeloma of all ages.

Original languageEnglish (US)
Pages (from-to)2850-2857
Number of pages8
JournalLeukemia and Lymphoma
Volume55
Issue number12
DOIs
StatePublished - Dec 1 2014
Externally publishedYes

Keywords

  • Clinical results
  • Myeloma
  • Prognostication

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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    Libby, E., Garcia, D., Quintana, D., Fekrazad, M. H., Bauman, J., Ebaid, A., Hromas, R., Rabinowitz, I., & Wiggins, C. (2014). Disease-specific survival for patients with multiple myeloma: Significant improvements over time in all age groups. Leukemia and Lymphoma, 55(12), 2850-2857. https://doi.org/10.3109/10428194.2014.897700