Discriminative Stimulus Effects of the Cannabinoid Antagonist, SR 141716A, in Δ9-Tetrahydrocannabinol-Treated Rhesus Monkeys

Lance R. McMahon; Charles P. France

doi:10.1037/1064-1297.11.4.286

Discriminative Stimulus Effects of the Cannabinoid Antagonist, SR 141716A, in Δ⁹-Tetrahydrocannabinol-Treated Rhesus Monkeys

Lance R. McMahon, Charles P. France

Department of Pharmacology

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

This study examined whether the cannabinoid antagonist, SR 141716A, could be established as a discriminative stimulus in rhesus monkeys treated with Δ⁹-tetrahydrocannabinol (Δ⁹-THC). Stimulus control was established with SR 141716A (1.0 mg/kg) in 3 Δ ⁹-THC-treated monkeys (1.12 mg/kg/day) in 113-124 sessions. The SR 141716A discriminative stimulus was dose related, attenuated by an acute injection of Δ⁹-THC, and not mimicked by cocaine or ketamine. SR 141716A-appropriate responding occasioned by temporary discontinuation of Δ⁹-THC treatment was attenuated by Δ⁹-THC and not ketamine. The SR 141716A discriminative stimulus in Δ ⁹-THC-treated monkeys appears to be mediated by cannabinoid receptors and could be related to Δ⁹-THC withdrawal.

Original language	English (US)
Pages (from-to)	286-293
Number of pages	8
Journal	Experimental and Clinical Psychopharmacology
Volume	11
Issue number	4
DOIs	https://doi.org/10.1037/1064-1297.11.4.286
State	Published - Nov 2003

ASJC Scopus subject areas

Pharmacology
Psychiatry and Mental health
Pharmacology (medical)

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abstract = "This study examined whether the cannabinoid antagonist, SR 141716A, could be established as a discriminative stimulus in rhesus monkeys treated with Δ9-tetrahydrocannabinol (Δ9-THC). Stimulus control was established with SR 141716A (1.0 mg/kg) in 3 Δ 9-THC-treated monkeys (1.12 mg/kg/day) in 113-124 sessions. The SR 141716A discriminative stimulus was dose related, attenuated by an acute injection of Δ9-THC, and not mimicked by cocaine or ketamine. SR 141716A-appropriate responding occasioned by temporary discontinuation of Δ9-THC treatment was attenuated by Δ9-THC and not ketamine. The SR 141716A discriminative stimulus in Δ 9-THC-treated monkeys appears to be mediated by cannabinoid receptors and could be related to Δ9-THC withdrawal.",

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Discriminative Stimulus Effects of the Cannabinoid Antagonist, SR 141716A, in Δ⁹-Tetrahydrocannabinol-Treated Rhesus Monkeys

Abstract

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