Discriminative Stimulus Effects of the Cannabinoid Antagonist, SR 141716A, in Δ9-Tetrahydrocannabinol-Treated Rhesus Monkeys

Lance R. McMahon, Charles P. France

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


This study examined whether the cannabinoid antagonist, SR 141716A, could be established as a discriminative stimulus in rhesus monkeys treated with Δ9-tetrahydrocannabinol (Δ9-THC). Stimulus control was established with SR 141716A (1.0 mg/kg) in 3 Δ 9-THC-treated monkeys (1.12 mg/kg/day) in 113-124 sessions. The SR 141716A discriminative stimulus was dose related, attenuated by an acute injection of Δ9-THC, and not mimicked by cocaine or ketamine. SR 141716A-appropriate responding occasioned by temporary discontinuation of Δ9-THC treatment was attenuated by Δ9-THC and not ketamine. The SR 141716A discriminative stimulus in Δ 9-THC-treated monkeys appears to be mediated by cannabinoid receptors and could be related to Δ9-THC withdrawal.

Original languageEnglish (US)
Pages (from-to)286-293
Number of pages8
JournalExperimental and Clinical Psychopharmacology
Issue number4
StatePublished - Nov 2003

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)


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