Discriminative stimulus effects of monohydroxylated phencyclidine metabolites in rhesus monkeys

Robert E. Solomon, Seymore Herling, James H. Woods

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Rhesus monkeys were trained to discriminate saline from an injection of ketamine. In tests of stimulus generalization, phencyclidine (PCP) produced dose-related ketamine-appropriate responding in each monkey. Two monohydroxylated PCP metabolites also produced ketamine-like discriminative effects, although only at considerably higher doses than did PCP. A third monohydroxylated PCP metabolite produced only sham-appropriate responding. The results suggest that these PCP metabolites contribute little to the behavioral actions of PCP in the monkey.

Original languageEnglish (US)
Pages (from-to)233-237
Number of pages5
JournalEuropean Journal of Pharmacology
Volume82
Issue number3-4
DOIs
StatePublished - Aug 27 1982
Externally publishedYes

Keywords

  • Discriminative stimulus effects
  • Ketamine
  • Phencyclidine
  • Phencyclidine metabolites
  • Rhesus monkeys

ASJC Scopus subject areas

  • Pharmacology

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