Discriminative stimulus effects of etorphine in rhesus monkeys

Seymore Herling, James H. Woods

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Two rhesus monkeys were trained to discriminate the IM injection of etorphine (0.001 mg/kg) from saline in a task in which 20 consecutive responses on one of two levers resulted in food delivery. In both monkeys, etorphine (0.0001-0.0018), meperidine (0.1-1.0 mg/kg), morphine (0.1-3.2 mg/kg), and codeine (0.3-3.2) produced dose-related increases in the percentage of total session responses that occurred on the etorphine-appropriate lever. In contrast, ethylketazocine, SKF-10047, and pentazocine, at doses up to and including those that suppressed response rates, produced responses primarily on the saline-appropriate lever. Thus, etorphine-like narcotics, including morphine, have discriminative stimulus effects in rhesus monkeys which can be distinguished from those produced by narcotics with nonmorphine-like actions such as ethylketazocine, SKF-10047, and pentazocine.

Original languageEnglish (US)
Pages (from-to)265-267
Number of pages3
JournalPsychopharmacology
Volume72
Issue number3
DOIs
StatePublished - Mar 1981
Externally publishedYes

Keywords

  • Drug discrimination
  • Etorphine
  • Rhesus monkeys

ASJC Scopus subject areas

  • Pharmacology

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