Discriminative and aversive properties of β-carboline-3-carboxylic acid ethyl ester, a benzodiazepine receptor inverse agonist, in rhesus monkey

Kohji Takada, Gail Winger, J. Cook, P. Larscheid, James H. Woods

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Rhesus monkeys were trained to discriminate injections of saline from those of β-carboline-3-carboxylic acid ethyl ester (β-CCE), a compound that binds to the benzodiazepine receptor, but often has actions opposite to those of the benzodiazepines. A benzodiazepine agonist midazolam and low doses of a specific benzodiazepine antagonist, Ro 15-1788, reversed the discriminative effects of β-CCE. Higher doses of Ro 15-1788 produced stimulus effects similar to β-CCE. In a separate experiment, monkeys responded to terminate intravenous infusions of β-CCE, but not midazolam. This aversive effect of β-CCE was reversed by Ro 15-1788. The behavioral effects of β-CCE in these non-human primates are consistent with other data that have shown it to act on benzodiazepine receptors, and support the hypothesis that β-CCE can be considered an inverse agonist at this receptor.

Original languageEnglish (US)
Pages (from-to)1049-1056
Number of pages8
JournalLife Sciences
Volume38
Issue number11
DOIs
StatePublished - Mar 17 1986
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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