Discovery of herpes B virus-encoded MicroRNAs

Michael I. Besecker, Mallory E. Harden, Guanglin Li, Xiu Jie Wang, Anthony Griffiths

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Herpes B virus (BV) naturally infects macaque monkeys and is a close relative of herpes simplex virus. BV can zoonotically infect humans to cause a rapidly ascending encephalitis with ∼80% mortality. Therefore, BV is a serious danger to those who come into contact with these monkeys or their tissues and cells. MicroRNAs are regulators of gene expression, and there have been reports of virus-encoded microRNAs. We hypothesize that BV-encoded microRNAs are important for the regulation of viral and cellular genes. Herein, we report the discovery of three herpes B virus-encoded microRNAs.

Original languageEnglish (US)
Pages (from-to)3413-3416
Number of pages4
JournalJournal of virology
Volume83
Issue number7
DOIs
StatePublished - Apr 2009
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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