Discovery of herpes B virus-encoded MicroRNAs

Michael I. Besecker; Mallory E. Harden; Guanglin Li; Xiu Jie Wang; Anthony Griffiths

doi:10.1128/JVI.02419-08

Discovery of herpes B virus-encoded MicroRNAs

Michael I. Besecker, Mallory E. Harden, Guanglin Li, Xiu Jie Wang, Anthony Griffiths

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Herpes B virus (BV) naturally infects macaque monkeys and is a close relative of herpes simplex virus. BV can zoonotically infect humans to cause a rapidly ascending encephalitis with ∼80% mortality. Therefore, BV is a serious danger to those who come into contact with these monkeys or their tissues and cells. MicroRNAs are regulators of gene expression, and there have been reports of virus-encoded microRNAs. We hypothesize that BV-encoded microRNAs are important for the regulation of viral and cellular genes. Herein, we report the discovery of three herpes B virus-encoded microRNAs.

Original language	English (US)
Pages (from-to)	3413-3416
Number of pages	4
Journal	Journal of virology
Volume	83
Issue number	7
DOIs	https://doi.org/10.1128/JVI.02419-08
State	Published - Apr 2009

ASJC Scopus subject areas

Microbiology
Immunology
Insect Science
Virology

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title = "Discovery of herpes B virus-encoded MicroRNAs",

abstract = "Herpes B virus (BV) naturally infects macaque monkeys and is a close relative of herpes simplex virus. BV can zoonotically infect humans to cause a rapidly ascending encephalitis with ∼80% mortality. Therefore, BV is a serious danger to those who come into contact with these monkeys or their tissues and cells. MicroRNAs are regulators of gene expression, and there have been reports of virus-encoded microRNAs. We hypothesize that BV-encoded microRNAs are important for the regulation of viral and cellular genes. Herein, we report the discovery of three herpes B virus-encoded microRNAs.",

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AU - Besecker, Michael I.

AU - Harden, Mallory E.

AU - Li, Guanglin

AU - Wang, Xiu Jie

AU - Griffiths, Anthony

PY - 2009/4

Y1 - 2009/4

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AB - Herpes B virus (BV) naturally infects macaque monkeys and is a close relative of herpes simplex virus. BV can zoonotically infect humans to cause a rapidly ascending encephalitis with ∼80% mortality. Therefore, BV is a serious danger to those who come into contact with these monkeys or their tissues and cells. MicroRNAs are regulators of gene expression, and there have been reports of virus-encoded microRNAs. We hypothesize that BV-encoded microRNAs are important for the regulation of viral and cellular genes. Herein, we report the discovery of three herpes B virus-encoded microRNAs.

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