Discovery and development of lamotrigine for bipolar disorder: A story of serendipity, clinical observations, risk taking, and persistence

Richard H. Weisler, Joseph R. Calabrese, Charles L. Bowden, John A. Ascher, Joseph DeVeaugh-Geiss, Gary Evoniuk

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

This paper briefly reviews and comments on the development of lamotrigine as a treatment for bipolar disorder. The events described include astute clinical observations by epileptologists, serendipitous coupling of the drug's clinical profile to unmet need of two refractory bipolar patients by a practicing psychiatrist, risk taking on the part of an industry sponsor, and persistence on the part of a few key internal and external advocates to see development through to its conclusion, taking place against a backdrop of a disease area which, at the time of the earliest events described here, had not seen the development of any new pharmacologic treatments for decades. Fortunately for patients, since that time there has been a veritable explosion of research into treatments for bipolar disorder, both old and new, so that now patients and physicians have multiple evidence-based options for the treatment of this devastating illness. The development of lamotrigine provides one example of the importance of prescience, patience and persistence in bringing a novel idea to clinical fruition.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalJournal of Affective Disorders
Volume108
Issue number1-2
DOIs
StatePublished - May 2008

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Risk-Taking
Bipolar Disorder
Explosions
Therapeutics
Psychiatry
Industry
Physicians
lamotrigine
Research
Pharmaceutical Preparations

Keywords

  • Bipolar disorder
  • Carbamazepine
  • Lamotrigine
  • Lithium

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Biological Psychiatry
  • Neurology
  • Psychology(all)

Cite this

Discovery and development of lamotrigine for bipolar disorder : A story of serendipity, clinical observations, risk taking, and persistence. / Weisler, Richard H.; Calabrese, Joseph R.; Bowden, Charles L.; Ascher, John A.; DeVeaugh-Geiss, Joseph; Evoniuk, Gary.

In: Journal of Affective Disorders, Vol. 108, No. 1-2, 05.2008, p. 1-9.

Research output: Contribution to journalArticle

Weisler, Richard H. ; Calabrese, Joseph R. ; Bowden, Charles L. ; Ascher, John A. ; DeVeaugh-Geiss, Joseph ; Evoniuk, Gary. / Discovery and development of lamotrigine for bipolar disorder : A story of serendipity, clinical observations, risk taking, and persistence. In: Journal of Affective Disorders. 2008 ; Vol. 108, No. 1-2. pp. 1-9.
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