Disability as a determinant of fatigue in MS patients

Fernanda Machado Taveira, Nayara F.T. Braz, Elizabeth R. Comini-Frota, Antônio L. Teixeira, Renan B. Domingues

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Fatigue is one of the most frequent and disabling symptoms in multiple sclerosis (MS). Central, psychological, and peripheral factors may contribute to the occurrence of fatigue. Objectives: The current study aimed to evaluate potential fatigue determinants in patients with relapsing-remitting MS with a low functional impairment. Methods: We compared inflammatory markers, respiratory pressures, disability, and quality of life in 39 relapsing-remitting MS patients with and without fatigue. Results: Patients with relapsing-remitting MS with fatigue had higher Expanded Disability Status Scale scores (p = 0.002). We observed a significant association between the results of the Guy Neurological Disability Scale, the Functional Assessment of MS Quality of Life Rating Scale and the presence of fatigue (p < 0.05). Conclusions: The degree of functional impairment is a determinant for the presence of fatigue in MS patients, but respiratory function and inflammatory markers are not.

Original languageEnglish (US)
Pages (from-to)248-253
Number of pages6
JournalArquivos de neuro-psiquiatria
Issue number4
StatePublished - Apr 2019
Externally publishedYes


  • Fatigue
  • Inflammatio
  • Multiple sclerosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry


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