Directions of drug discovery in osteoporosis

Gregory R. Mundy

Research output: Contribution to journalReview articlepeer-review

35 Scopus citations

Abstract

Osteoporosis is a condition of increasing importance and prevalence in all parts of the world and particularly in Asia. Recent advances have led to the introduction of effective drugs that decrease bone resorption and stabilize bone mass. However, these drugs have been identified by serendipity rather than rational drug design and are not ideal because of limited bioavailability, mode of administration, or other unwanted effects. There is still a place for even more suitable and effective resorption inhibitors than those currently available. The more compelling need in this field is an acceptable drug that is anabolic for bone, that safely and acceptably increases bone mass and improves the disturbances in bone microarchitecture that characterize established and advanced osteoporosis. Possible approaches to identifying more effective resorption inhibitors and new anabolic agents are discussed.

Original languageEnglish (US)
Pages (from-to)337-354
Number of pages18
JournalAnnual review of medicine
Volume53
DOIs
StatePublished - 2002

Keywords

  • Bisphosphonates
  • Bone growth factors
  • Leptin
  • Osteoporosis
  • Statins

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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