Directional activation of intestinal dendritic cells by an oral targeted multivalent vaccine

Bikash Sahay, Jennifer L. Owen, Mansour Mohamadzadeh

Research output: Contribution to journalReview articlepeer-review


Parenteral injectionis the most common routeof administration for vaccines and therapeutics. Despite their frequent use, needle-based immunizations have several limitations; (i) needle phobias that are common in both adults and children, (ii) the requirement of trained medical personnel to administer vaccines, creating a limitation for mass vaccination, and (iii) accidental needle sticks, a serious concern in both developed and developing countries. Possible alternatives to injections have recently emerged and include (i) dermal and (ii) oral administration of vaccines. Here, we describe a methodology developed in our laboratory using intestinal bacteria that are considered safe for human consumption. Additionally, we have designed a dendritic cell (DC)-targeting sequence that delivers antigens directly to DCs. In this report, we discuss how DC-targeting peptide binding is not limited to human and murine antigen presenting cells; rather, it consistently binds with DCs of different species. Our data suggest that a DC-targeted oral vaccine platform could be used to develop vaccines for a variety of host animals.

Original languageEnglish (US)
JournalJournal of Vaccines and Vaccination
Issue number5
StatePublished - 2013
Externally publishedYes


  • Dendritic cells
  • Multivalent vaccine

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Drug Discovery
  • Virology


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