Direct resorption of bone by human monocytes

Gregory R. Mundy, Arnold J. Altman, Monica D. Gondek, Janet G. Bandelin

Research output: Contribution to journalArticlepeer-review

192 Scopus citations

Abstract

Cultured human peripheral blood monocytes stimulate the release of bone mineral and matrix from killed long bones of fetal rats. These effects were inhibited by cortisol but were not altered by hormones that normally stimulate osteoclastic bone resorption. There was no evidence of morphologic differentiation of the monocytes into osteoclasts during bone resorption.

Original languageEnglish (US)
Pages (from-to)1109-1111
Number of pages3
JournalScience
Volume196
Issue number4294
DOIs
StatePublished - 1977
Externally publishedYes

ASJC Scopus subject areas

  • General

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