Direct resorption of bone by human breast cancer cells in vitro [19]

Gabriel Eilon, Gregory R. Mundy

Research output: Contribution to journalLetterpeer-review

186 Scopus citations

Abstract

OSTEOLYTIC bone metastases occur frequency in patients with advanced malignancy. Breast cancer, the most common malignant disease of women, metastasises to bone more frequently than to any other organ1, and over 80% of patients with advanced breast cancer develop bone metastases 2-4. The cellular and molecular mechanisms of bone destruction in patients with cancer are not clearly understood. It has been postulated that there may be two mechanisms, one which is mediated by osteoclasts and one which occurs independently of osteoclasts5,6. We show here that cultured human breast cancer cells have the capacity to resorb directly in vitro, independently of osteoclast stimulation.

Original languageEnglish (US)
Pages (from-to)726-728
Number of pages3
JournalNature
Volume276
Issue number5689
DOIs
StatePublished - 1978
Externally publishedYes

ASJC Scopus subject areas

  • General

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