Direct regulation of osteocytic connexin 43 hemichannels through AKT kinase activated by mechanical stimulation

Nidhi Batra, Manuel A. Riquelme, Sirisha Burra, Rekha Kar, Sumin Gu, Jean X. Jiang

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

Background: Opening of Cx43 hemichannels by mechanical stress releases factors important for bone remodeling; however, the regulatory mechanism is unknown. Result: Upon mechanical stimulation, AKT phosphorylates integrinα5 and Cx43, increases interaction, and opens hemichannels. Conclusion: Phosphorylation of Cx43 andα5 by AKT is critical for hemichannel opening. Significance: This is the first report demonstrating the functional importance of AKT in regulation of Cx43 hemichannels.

Original languageEnglish (US)
Pages (from-to)10582-10591
Number of pages10
JournalJournal of Biological Chemistry
Volume289
Issue number15
DOIs
StatePublished - Apr 11 2014

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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