Direct regulation of osteocytic connexin 43 hemichannels through AKT kinase activated by mechanical stimulation

Nidhi Batra; Manuel A. Riquelme; Sirisha Burra; Rekha Kar; Sumin Gu; Jean X. Jiang

doi:10.1074/jbc.M114.550608

Direct regulation of osteocytic connexin 43 hemichannels through AKT kinase activated by mechanical stimulation

Nidhi Batra, Manuel A. Riquelme, Sirisha Burra, Rekha Kar, Sumin Gu, Jean X. Jiang

Research output: Contribution to journal › Article › peer-review

72 Scopus citations

Abstract

Background: Opening of Cx43 hemichannels by mechanical stress releases factors important for bone remodeling; however, the regulatory mechanism is unknown. Result: Upon mechanical stimulation, AKT phosphorylates integrinα5 and Cx43, increases interaction, and opens hemichannels. Conclusion: Phosphorylation of Cx43 andα5 by AKT is critical for hemichannel opening. Significance: This is the first report demonstrating the functional importance of AKT in regulation of Cx43 hemichannels.

Original language	English (US)
Pages (from-to)	10582-10591
Number of pages	10
Journal	Journal of Biological Chemistry
Volume	289
Issue number	15
DOIs	https://doi.org/10.1074/jbc.M114.550608
State	Published - Apr 11 2014

ASJC Scopus subject areas

Molecular Biology
Biochemistry
Cell Biology

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title = "Direct regulation of osteocytic connexin 43 hemichannels through AKT kinase activated by mechanical stimulation",

abstract = "Background: Opening of Cx43 hemichannels by mechanical stress releases factors important for bone remodeling; however, the regulatory mechanism is unknown. Result: Upon mechanical stimulation, AKT phosphorylates integrinα5 and Cx43, increases interaction, and opens hemichannels. Conclusion: Phosphorylation of Cx43 andα5 by AKT is critical for hemichannel opening. Significance: This is the first report demonstrating the functional importance of AKT in regulation of Cx43 hemichannels.",

author = "Nidhi Batra and Riquelme, {Manuel A.} and Sirisha Burra and Rekha Kar and Sumin Gu and Jiang, {Jean X.}",

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T1 - Direct regulation of osteocytic connexin 43 hemichannels through AKT kinase activated by mechanical stimulation

AU - Batra, Nidhi

AU - Riquelme, Manuel A.

AU - Burra, Sirisha

AU - Kar, Rekha

AU - Gu, Sumin

AU - Jiang, Jean X.

PY - 2014/4/11

Y1 - 2014/4/11

N2 - Background: Opening of Cx43 hemichannels by mechanical stress releases factors important for bone remodeling; however, the regulatory mechanism is unknown. Result: Upon mechanical stimulation, AKT phosphorylates integrinα5 and Cx43, increases interaction, and opens hemichannels. Conclusion: Phosphorylation of Cx43 andα5 by AKT is critical for hemichannel opening. Significance: This is the first report demonstrating the functional importance of AKT in regulation of Cx43 hemichannels.

AB - Background: Opening of Cx43 hemichannels by mechanical stress releases factors important for bone remodeling; however, the regulatory mechanism is unknown. Result: Upon mechanical stimulation, AKT phosphorylates integrinα5 and Cx43, increases interaction, and opens hemichannels. Conclusion: Phosphorylation of Cx43 andα5 by AKT is critical for hemichannel opening. Significance: This is the first report demonstrating the functional importance of AKT in regulation of Cx43 hemichannels.

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Direct regulation of osteocytic connexin 43 hemichannels through AKT kinase activated by mechanical stimulation

Abstract

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