Abstract
When B lymphocytes from normal human peripheral blood were incubated for 1 hour with the retrovirus that causes the acquired immune deficiency syndrome (AIDS), the B cells showed marked proliferation and differentiation. Proliferative responses to the virus peaked on day 4 and appeared to be independent of accessory cells. This finding was repeated with three separate viral isolates, one of which was from a patient from Zaire. The magnitude of the observed responses was comparable to that seen with standard polyclonal B-cell activators. This phenomenon may be at least partially responsible for the polyclonal B-cell activation seen in patients with AIDS.
Original language | English (US) |
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Pages (from-to) | 1084-1086 |
Number of pages | 3 |
Journal | Science |
Volume | 233 |
Issue number | 4768 |
DOIs | |
State | Published - Jan 1 1986 |
ASJC Scopus subject areas
- General