Abstract
When B lymphocytes from normal human peripheral blood were incubated for 1 hour with the retrovirus that causes the acquired immune deficiency syndrome (AIDS), the B cells showed marked proliferation and differentiation. Proliferative responses to the virus peaked on day 4 and appeared to be independent of accessory cells. This finding was repeated with three separate viral isolates, one of which was from a patient from Zaire. The magnitude of the observed responses was comparable to that seen with standard polyclonal B-cell activators. This phenomenon may be at least partially responsible for the polyclonal B-cell activation seen in patients with AIDS.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1084-1086 |
| Number of pages | 3 |
| Journal | Science |
| Volume | 233 |
| Issue number | 4768 |
| DOIs | |
| State | Published - Jan 1 1986 |
ASJC Scopus subject areas
- General
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Schnittman, S. M., Lane, H. C., Higgins, S. E., Folks, T., & Fauci, A. S. (1986). Direct polyclonal activation of human B lymphocytes by the acquired immune deficiency syndrome virus. Science, 233(4768), 1084-1086. https://doi.org/10.1126/science.3016902