Direct polyclonal activation of human B lymphocytes by the acquired immune deficiency syndrome virus

Steven M. Schnittman, H. Clifford Lane, Sandra E. Higgins, Thomas Folks, Anthony S. Fauci

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    262 Scopus citations

    Abstract

    When B lymphocytes from normal human peripheral blood were incubated for 1 hour with the retrovirus that causes the acquired immune deficiency syndrome (AIDS), the B cells showed marked proliferation and differentiation. Proliferative responses to the virus peaked on day 4 and appeared to be independent of accessory cells. This finding was repeated with three separate viral isolates, one of which was from a patient from Zaire. The magnitude of the observed responses was comparable to that seen with standard polyclonal B-cell activators. This phenomenon may be at least partially responsible for the polyclonal B-cell activation seen in patients with AIDS.

    Original languageEnglish (US)
    Pages (from-to)1084-1086
    Number of pages3
    JournalScience
    Volume233
    Issue number4768
    DOIs
    StatePublished - Jan 1 1986

    ASJC Scopus subject areas

    • General

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    Schnittman, S. M., Lane, H. C., Higgins, S. E., Folks, T., & Fauci, A. S. (1986). Direct polyclonal activation of human B lymphocytes by the acquired immune deficiency syndrome virus. Science, 233(4768), 1084-1086. https://doi.org/10.1126/science.3016902