Three excitatory amino acid agonists [N-methyl-D-aspartate (NMDA), kainate and α-amino-2,3-dihyro-5-methyl-3-oxo-4-isoxalzolepropanoic acid], each selective for separate glutamate binding sites, were evaluated for dipsogenic responses in pigeons. NMDA and kainate produced a reliable and rapid drinking response (up to 30% of body weight over 3 hr). α-amino-2,3-dihyro-5-methyl- 3-oxo-4-isoxalzolepropanoic acid, up to doses which produced profound effects on motor behavior (18.0 mg/kg i.m.), did not produce a reliable drinking response. The dipsogenic effects of NMDA and its stereoisomer, N-methyl-L- aspartate, were antagonized by the competitive NMDA antagonist, cis-4- (phosphonomethyl)-2-piperidinecarboxylic acid, cis-4-(phosphonomethyl)-2- Piperidinecarboxylic acid failed to prevent drinking produced by kainate or water deprivation. These results suggest that NMDA-, kainate- and water deprivation-induced drinking are mediated via separate mechanisms and that NMDA induced drinking is mediated via NMDA receptors.
|Original language||English (US)|
|Number of pages||4|
|Journal||Journal of Pharmacology and Experimental Therapeutics|
|State||Published - 1993|
ASJC Scopus subject areas
- Molecular Medicine