Dimorphism and haploid fruiting in Cryptococcus neoformans: Association with the α-mating type

Brian L. Wickes, María E. Mayorga, Ursula Edman, Jeffrey C. Edman

Research output: Contribution to journalArticlepeer-review

235 Scopus citations

Abstract

Cryptococcus neoformans is a major opportunistic fungal pathogen in AIDS and other immunosuppressed patients. We have shown that wild-type haploid C. neoformans can develop an extensive hyphal phase under appropriate conditions. Hyphae produced under these conditions are monokaryotic, possess unfused clamp connections, and develop basidia with viable basidiospores. The ability to undergo this transition is determined by the presence of the α- mating type locus and is independent of serotype. The association of the hyphal phase with the α-mating type may explain the preponderance of this mating type in the environment and the nature of the infectious propagule of C. neoformans.

Original languageEnglish (US)
Pages (from-to)7327-7331
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume93
Issue number14
DOIs
StatePublished - Jul 9 1996

Keywords

  • clamp connection
  • dikaryotic
  • hyphae
  • monokaryotic

ASJC Scopus subject areas

  • General

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