Diminished vancomycin and daptomycin susceptibility during prolonged bacteremia with methicillin-resistant Staphylococcus aureus

Jason W. Bennett, Clinton K. Murray, Robert L. Holmes, Jan E. Patterson, James H. Jorgensen

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

An elderly patient with methicillin-resistant Staphylococcus aureus (MRSA) bacteremia was treated sequentially with vancomycin plus rifampin then daptomycin plus gentamicin. The MRSA strain developed diminished susceptibility to vancomycin (MIC increase and tolerance), daptomycin, and gentamicin, and resistance to rifampin during therapy.

Original languageEnglish (US)
Pages (from-to)437-440
Number of pages4
JournalDiagnostic Microbiology and Infectious Disease
Volume60
Issue number4
DOIs
StatePublished - Apr 1 2008

Keywords

  • Bactericidal effect
  • Daptomycin resistance
  • MRSA bacteremia
  • Minimum inhibitory concentration
  • Vancomycin tolerance

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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