Diminished Response to Glucagon in the Dextrose-Primed Neonate

Rosita S. Pildes, Rajam S. Ramamurthy, Daksha A. Patel

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


The response to exogenous glucagon in hypoglycemic newborns, control newborns, and infants and children who had been primed with intravenously administered dextrose was evaluated. Dextrose (1 gm/kg) was injected rapidly, and, at 60 minutes, glucagon (0.03 to 0.3 mg/kg) was injected and blood glucose values measured every 15 minutes for one hour. In the infants and children, glucose values following the injection of glucagon rose 43 ± 3 mg/100 ml at 15 minutes and returned to preglucagon values (zero time) by 60 minutes. In both hypoglycemic and control newborns, glucose values following glucagon injection were lower after 15 minutes and continued to fall during the entire 60 minutes. The response to glucagon was significantly less (P<.001) at each time period in the newborn groups when compared to that in the infants and children.

Original languageEnglish (US)
Pages (from-to)333-335
Number of pages3
JournalAmerican Journal of Diseases of Children
Issue number3
StatePublished - Mar 1974
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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