Diminished Immune Response in Sun-Damaged Skin

Bruce L. O'dell, R. Thomas Jessen, Larry E. Becker, Ross T. Jackson, Edgar B. Smith

Research output: Contribution to journalArticlepeer-review

66 Scopus citations


In previously sensitized volunteers, higher concentrations of 2,4-dinitrochlorobenzene were necessary to elicit positive patch test reactions on the sundamaged skin of the neck than on the protected skin of the upper part of the back. This difference was not found in subjects without evidence of sun damage, and there was no difference between sundamaged and nondamaged skin in response to a primary irritant. Responses to intradermally injected common antigens were also less intense in sun-damaged skin than in nonexposed skin. These findings suggest the existence of a local defect in cell-mediated immunity in skin altered by long-term sun exposure.

Original languageEnglish (US)
Pages (from-to)559-561
Number of pages3
JournalArchives of Dermatology
Issue number5
StatePublished - May 1980
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology


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