Diffusion-weighted imaging in cancer: Physical foundations and applications of restriction spectrum imaging

Nathan S. White, Carrie R. McDonald, Niky Farid, Josh Kuperman, David Karow, Natalie M. Schenker-Ahmed, Hauke Bartsch, Rebecca Rakow-Penner, Dominic Holland, Ahmed Shabaik, Atle Bjørnerud, Tuva Hope, Jona Hattangadi-Gluth, Michael A Liss, J. Kellogg Parsons, Clark C. Chen, Steve Raman, Daniel Margolis, Robert E. Reiter, Leonard MarksSantosh Kesari, Arno J. Mundt, Christopher J. Kaine, Bob S. Carter, William G. Bradley, Anders M. Dale

Research output: Contribution to journalReview article

51 Citations (Scopus)

Abstract

Diffusion-weighted imaging (DWI) has been at the forefront of cancer imaging since the early 2000s. Before its application in clinical oncology, this powerful technique had already achieved widespread recognition due to its utility in the diagnosis of cerebral infarction. Following this initial success, the ability of DWI to detect inherent tissue contrast began to be exploited in the field of oncology. Although the initial oncologic applications for tumor detection and characterization, assessing treatment response, and predicting survival were primarily in the field of neurooncology, the scope of DWI has since broadened to include oncologic imaging of the prostate gland, breast, and liver. Despite its growing success and application, misconceptions about the underlying physical basis of the DWI signal exist among researchers and clinicians alike. In this review, we provide a detailed explanation of the biophysical basis of diffusion contrast, emphasizing the difference between hindered and restricted diffusion, and elucidating how diffusion parameters in tissue are derived from the measurements via the diffusion model. We describe one advanced DWI modeling technique, called restriction spectrum imaging (RSI). This technique offers a more direct in vivo measure of tumor cells, due to its ability to distinguish separable pools of water within tissue based on their intrinsic diffusion characteristics. Using RSI as an example, we then highlight the ability of advanced DWI techniques to address key clinical challenges in neurooncology, including improved tumor conspicuity, distinguishing actual response to therapy from pseudoresponse, and delineation of white matter tracts in regions of peritumoral edema. We also discuss how RSI, combined with new methods for correction of spatial distortions inherent in diffusion MRI scans, may enable more precise spatial targeting of lesions, with implications for radiation oncology and surgical planning.

Original languageEnglish (US)
Pages (from-to)4638-4652
Number of pages15
JournalCancer Research
Volume74
Issue number17
DOIs
StatePublished - Sep 1 2014
Externally publishedYes

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Neoplasms
Radiation Oncology
Diffusion Magnetic Resonance Imaging
Medical Oncology
Cerebral Infarction
Prostate
Edema
Breast
Research Personnel
Magnetic Resonance Imaging
Water
Liver
Therapeutics

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

White, N. S., McDonald, C. R., Farid, N., Kuperman, J., Karow, D., Schenker-Ahmed, N. M., ... Dale, A. M. (2014). Diffusion-weighted imaging in cancer: Physical foundations and applications of restriction spectrum imaging. Cancer Research, 74(17), 4638-4652. https://doi.org/10.1158/0008-5472.CAN-13-3534

Diffusion-weighted imaging in cancer : Physical foundations and applications of restriction spectrum imaging. / White, Nathan S.; McDonald, Carrie R.; Farid, Niky; Kuperman, Josh; Karow, David; Schenker-Ahmed, Natalie M.; Bartsch, Hauke; Rakow-Penner, Rebecca; Holland, Dominic; Shabaik, Ahmed; Bjørnerud, Atle; Hope, Tuva; Hattangadi-Gluth, Jona; Liss, Michael A; Parsons, J. Kellogg; Chen, Clark C.; Raman, Steve; Margolis, Daniel; Reiter, Robert E.; Marks, Leonard; Kesari, Santosh; Mundt, Arno J.; Kaine, Christopher J.; Carter, Bob S.; Bradley, William G.; Dale, Anders M.

In: Cancer Research, Vol. 74, No. 17, 01.09.2014, p. 4638-4652.

Research output: Contribution to journalReview article

White, NS, McDonald, CR, Farid, N, Kuperman, J, Karow, D, Schenker-Ahmed, NM, Bartsch, H, Rakow-Penner, R, Holland, D, Shabaik, A, Bjørnerud, A, Hope, T, Hattangadi-Gluth, J, Liss, MA, Parsons, JK, Chen, CC, Raman, S, Margolis, D, Reiter, RE, Marks, L, Kesari, S, Mundt, AJ, Kaine, CJ, Carter, BS, Bradley, WG & Dale, AM 2014, 'Diffusion-weighted imaging in cancer: Physical foundations and applications of restriction spectrum imaging', Cancer Research, vol. 74, no. 17, pp. 4638-4652. https://doi.org/10.1158/0008-5472.CAN-13-3534
White, Nathan S. ; McDonald, Carrie R. ; Farid, Niky ; Kuperman, Josh ; Karow, David ; Schenker-Ahmed, Natalie M. ; Bartsch, Hauke ; Rakow-Penner, Rebecca ; Holland, Dominic ; Shabaik, Ahmed ; Bjørnerud, Atle ; Hope, Tuva ; Hattangadi-Gluth, Jona ; Liss, Michael A ; Parsons, J. Kellogg ; Chen, Clark C. ; Raman, Steve ; Margolis, Daniel ; Reiter, Robert E. ; Marks, Leonard ; Kesari, Santosh ; Mundt, Arno J. ; Kaine, Christopher J. ; Carter, Bob S. ; Bradley, William G. ; Dale, Anders M. / Diffusion-weighted imaging in cancer : Physical foundations and applications of restriction spectrum imaging. In: Cancer Research. 2014 ; Vol. 74, No. 17. pp. 4638-4652.
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AU - Karow, David

AU - Schenker-Ahmed, Natalie M.

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AU - Marks, Leonard

AU - Kesari, Santosh

AU - Mundt, Arno J.

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