Diffusion in musculoskeletal tissue engineering scaffolds: Design issues related to porosity, permeability, architecture, and nutrient mixing

Tejas S. Karande, Joo L. Ong, C. Mauli Agrawal

Research output: Contribution to journalArticlepeer-review

343 Scopus citations

Abstract

The field of tissue engineering continues to advance with the discovery of new biomaterials, growth factors and scaffold fabrication techniques. However, for the ultimate success of a tissue engineered construct the issue of nutrient transport to the scaffold interior needs to be addressed. Often, the requirements for adequate nutrient supply are at odds with other scaffold design parameters such as mechanical properties as well as scaffold fabrication techniques, leading to incongruities in finding optimal solutions. The goal of this review article is to provide an overview of the various engineering design factors that promote movement of nutrients, waste and other biomolecules in scaffolds for musculoskeletal tissue engineering applications. The importance of diffusion in scaffolds and how it is influenced by porosity, permeability, architecture, and nutrient mixing has been emphasized. Methods for measuring porosity and permeability have also been outlined. The different types of biomaterials used, scaffold fabrication techniques implemented and the pore sizes/porosities obtained over the past 5 years have also been addressed.

Original languageEnglish (US)
Pages (from-to)1728-1743
Number of pages16
JournalAnnals of Biomedical Engineering
Volume32
Issue number12
DOIs
StatePublished - Dec 2004

Keywords

  • Nutrient transport
  • Pore interconnectivity
  • Scaffold fabrication techniques

ASJC Scopus subject areas

  • Biomedical Engineering

Fingerprint Dive into the research topics of 'Diffusion in musculoskeletal tissue engineering scaffolds: Design issues related to porosity, permeability, architecture, and nutrient mixing'. Together they form a unique fingerprint.

Cite this