Differentiation: The selective potentiation of chromatin domains

Jeffrey A. Kramer, John R. McCarrey, Daniel Djakiew, Stephen A. Krawetz

Research output: Contribution to journalArticlepeer-review

57 Scopus citations

Abstract

Potentiation is requisite for the expression of our genome. It is the mechanism of opening chromatin domains to render genes accessible to tissue-specific and ubiquitous transacting-factors that enables transcription. The results presented in this study demonstrate that modulation of stage- and cell-type-specific gene expression during mammalian spermatogenesis involves selective potentiation of testis-expressed genes that reverses their repressive state when present in the spermatogonial stem cell. This directly contrasts hematopoiesis, which acts to selectively restrict lineage potential during differentiation from its permissive stem cell. These results are key to understanding how differentiative pathways are controlled and cellular phenotypes determined. A window to their modulation is presented.

Original languageEnglish (US)
Pages (from-to)4749-4755
Number of pages7
JournalDevelopment
Volume125
Issue number23
StatePublished - 1998
Externally publishedYes

Keywords

  • Chromatin structure
  • Commitment
  • Determination
  • Phosphoglycerate kinase
  • Potentiation
  • Protamine
  • Spermatogenesis

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology

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