Differentially delayed development in the hand–wrist skeletons of children with cystic fibrosis: Round versus tubular bones

Michael C. Mahaney

Research output: Contribution to journalArticle

1 Scopus citations


From a sample of 50 cystic fibrosis patients in whom a previous study had demosntrated a lack of statistical interdependence between disease severity and significant TW2–20 bone age delays, hand–wrist radiographs for a preadolescent subsample of 30 (14 females and 16 males, 7.4 to 13.0 years of age) are reassessed using the TW2 method to (1) elucidate any significant differences in maturational delays exhibited by the carpals and the tubular bones (radius, ulna, and short bones [RUS]) of the hand–wrist complex and (2) assess the relationships between the clinically derived measure of pulmonary disease severity, anthropometric indices of nutritional status, and the bone age delays in these two regions. Female and male carpal bone age delays, pulmonary disease severity scores, and weight/height2 differ significantly. However, both sexes exhibit significant mean TW2–carpal bone age delays, while mean TW2‐RUS ages are either non‐significantly delayed or advanced with respect to normative standards. Correlation and all‐subsets multiple linear regression analyses reveal no significant interdependence or predictive relationships between clinically derived measures of pulmonary disease severity and anthropometric measures of nutritional complications and delayed skeletal maturation in either the carpals or tubular bones of the hand–wrist complex.

Original languageEnglish (US)
Pages (from-to)17-24
Number of pages8
JournalAmerican Journal of Human Biology
Issue number1
Publication statusPublished - 1991
Externally publishedYes


ASJC Scopus subject areas

  • Anatomy
  • Ecology, Evolution, Behavior and Systematics
  • Anthropology
  • Genetics

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