Abstract
The effectiveness of acetolysis as a tool in structural characterization of mono- and di-O-alkyl phosphoglycerides was investigated. Surprisingly, it was found that the di-O-alkyl phosphoglycerides were resistant to attack during acetolysis, whereas the mono-ether types, with a free hydroxyl function or an ester on carbon-2, were easily attacked at the glycerol-phosphate bond. On the other hand, Vitride reduction occurred readily with the mono-ether or di-ether phosphoglycerides. The implications of these findings as they relate to identification of ether phospholipids in tissues are discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 930-937 |
| Number of pages | 8 |
| Journal | Journal of Lipid Research |
| Volume | 24 |
| Issue number | 7 |
| State | Published - Jul 1983 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Endocrinology
Cite this
Differential susceptibility of mono- and di-O-alkyl ether phosphoglycerides to acetolysis. / Kumar, R.; Weintraub, Susan E; Hanahan, D. J.
In: Journal of Lipid Research, Vol. 24, No. 7, 07.1983, p. 930-937.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Differential susceptibility of mono- and di-O-alkyl ether phosphoglycerides to acetolysis.
AU - Kumar, R.
AU - Weintraub, Susan E
AU - Hanahan, D. J.
PY - 1983/7
Y1 - 1983/7
N2 - The effectiveness of acetolysis as a tool in structural characterization of mono- and di-O-alkyl phosphoglycerides was investigated. Surprisingly, it was found that the di-O-alkyl phosphoglycerides were resistant to attack during acetolysis, whereas the mono-ether types, with a free hydroxyl function or an ester on carbon-2, were easily attacked at the glycerol-phosphate bond. On the other hand, Vitride reduction occurred readily with the mono-ether or di-ether phosphoglycerides. The implications of these findings as they relate to identification of ether phospholipids in tissues are discussed.
AB - The effectiveness of acetolysis as a tool in structural characterization of mono- and di-O-alkyl phosphoglycerides was investigated. Surprisingly, it was found that the di-O-alkyl phosphoglycerides were resistant to attack during acetolysis, whereas the mono-ether types, with a free hydroxyl function or an ester on carbon-2, were easily attacked at the glycerol-phosphate bond. On the other hand, Vitride reduction occurred readily with the mono-ether or di-ether phosphoglycerides. The implications of these findings as they relate to identification of ether phospholipids in tissues are discussed.
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UR - http://www.scopus.com/inward/citedby.url?scp=0020793699&partnerID=8YFLogxK
M3 - Article
C2 - 6631227
AN - SCOPUS:0020793699
VL - 24
SP - 930
EP - 937
JO - Journal of Lipid Research
JF - Journal of Lipid Research
SN - 0022-2275
IS - 7
ER -