Differential susceptibility of mono- and di-O-alkyl ether phosphoglycerides to acetolysis.

R. Kumar, S. T. Weintraub, D. J. Hanahan

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


The effectiveness of acetolysis as a tool in structural characterization of mono- and di-O-alkyl phosphoglycerides was investigated. Surprisingly, it was found that the di-O-alkyl phosphoglycerides were resistant to attack during acetolysis, whereas the mono-ether types, with a free hydroxyl function or an ester on carbon-2, were easily attacked at the glycerol-phosphate bond. On the other hand, Vitride reduction occurred readily with the mono-ether or di-ether phosphoglycerides. The implications of these findings as they relate to identification of ether phospholipids in tissues are discussed.

Original languageEnglish (US)
Pages (from-to)930-937
Number of pages8
JournalJournal of lipid research
Issue number7
StatePublished - Jul 1983

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Cell Biology


Dive into the research topics of 'Differential susceptibility of mono- and di-O-alkyl ether phosphoglycerides to acetolysis.'. Together they form a unique fingerprint.

Cite this