Differential subcellular distribution of neurolysin (EC 3.4.24.16) and thimet oligopeptidase (EC 3.4.24.15) in the rat brain

Eduardo E. Massarelli, Cláudio A. Casatti, Akira Kato, Antonio C.M. Camargo, Jarbas A. Bauer, Marc J. Glucksman, James L. Roberts, Shigehisa Hirose, Emer S. Ferro

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Immunohistochemistry was used to analyze the rat brain distribution of thimet oligopeptidase and neurolysin. Both enzymes appear ubiquitously distributed within the entire rat brain. However, neuronal perikarya and processes stained for neurolysin, while intense nuclear labeling was only observed for thimet oligopeptidase. These data suggest that neurolysin and thimet oligopeptidase, endopeptidases sharing several functional and structural similarities, are present in distinctive intracellular compartments in neuronal cells. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)261-265
Number of pages5
JournalBrain Research
Volume851
Issue number1-2
DOIs
StatePublished - Dec 18 1999

Keywords

  • Endopeptidase
  • Intracellular metabolism
  • Neuropeptide
  • Nuclear enzyme
  • Oligopeptidase
  • Peptide

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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