Differential subcellular distribution of neurolysin (EC 3.4.24.16) and thimet oligopeptidase (EC 3.4.24.15) in the rat brain

Eduardo E. Massarelli; Cláudio A. Casatti; Akira Kato; Antonio C.M. Camargo; Jarbas A. Bauer; Marc J. Glucksman; James L. Roberts; Shigehisa Hirose; Emer S. Ferro

doi:10.1016/S0006-8993(99)02135-6

Differential subcellular distribution of neurolysin (EC 3.4.24.16) and thimet oligopeptidase (EC 3.4.24.15) in the rat brain

Eduardo E. Massarelli, Cláudio A. Casatti, Akira Kato, Antonio C.M. Camargo, Jarbas A. Bauer, Marc J. Glucksman, James L. Roberts, Shigehisa Hirose, Emer S. Ferro

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Immunohistochemistry was used to analyze the rat brain distribution of thimet oligopeptidase and neurolysin. Both enzymes appear ubiquitously distributed within the entire rat brain. However, neuronal perikarya and processes stained for neurolysin, while intense nuclear labeling was only observed for thimet oligopeptidase. These data suggest that neurolysin and thimet oligopeptidase, endopeptidases sharing several functional and structural similarities, are present in distinctive intracellular compartments in neuronal cells. Copyright (C) 1999 Elsevier Science B.V.

Original language	English (US)
Pages (from-to)	261-265
Number of pages	5
Journal	Brain Research
Volume	851
Issue number	1-2
DOIs	https://doi.org/10.1016/S0006-8993(99)02135-6
State	Published - Dec 18 1999
Externally published	Yes

Keywords

Endopeptidase
Intracellular metabolism
Neuropeptide
Nuclear enzyme
Oligopeptidase
Peptide

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/S0006-8993(99)02135-6

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@article{9e162afbb7cb4a1ab95885296251f6e8,

title = "Differential subcellular distribution of neurolysin (EC 3.4.24.16) and thimet oligopeptidase (EC 3.4.24.15) in the rat brain",

abstract = "Immunohistochemistry was used to analyze the rat brain distribution of thimet oligopeptidase and neurolysin. Both enzymes appear ubiquitously distributed within the entire rat brain. However, neuronal perikarya and processes stained for neurolysin, while intense nuclear labeling was only observed for thimet oligopeptidase. These data suggest that neurolysin and thimet oligopeptidase, endopeptidases sharing several functional and structural similarities, are present in distinctive intracellular compartments in neuronal cells. Copyright (C) 1999 Elsevier Science B.V.",

keywords = "Endopeptidase, Intracellular metabolism, Neuropeptide, Nuclear enzyme, Oligopeptidase, Peptide",

author = "Massarelli, {Eduardo E.} and Casatti, {Cl{\'a}udio A.} and Akira Kato and Camargo, {Antonio C.M.} and Bauer, {Jarbas A.} and Glucksman, {Marc J.} and Roberts, {James L.} and Shigehisa Hirose and Ferro, {Emer S.}",

note = "Funding Information: This work was supported by FAPESP and CNPq. Thanks are also due to Ms. Patricia Helena Camargo Saben{\c c}a do Couto, Biochemistry Section, Butantan Institute, and Margareth Trentino Arroyo, Gabriela Kampf Cury, Edson Rocha de Oliveira and Roberto Cabado Modia Jr., Department of Histology and Embryology, University of S{\~a}o Paulo, for inestimable technical support.",

year = "1999",

month = dec,

day = "18",

doi = "10.1016/S0006-8993(99)02135-6",

language = "English (US)",

volume = "851",

pages = "261--265",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier",

number = "1-2",

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TY - JOUR

T1 - Differential subcellular distribution of neurolysin (EC 3.4.24.16) and thimet oligopeptidase (EC 3.4.24.15) in the rat brain

AU - Massarelli, Eduardo E.

AU - Casatti, Cláudio A.

AU - Kato, Akira

AU - Camargo, Antonio C.M.

AU - Bauer, Jarbas A.

AU - Glucksman, Marc J.

AU - Roberts, James L.

AU - Hirose, Shigehisa

AU - Ferro, Emer S.

N1 - Funding Information: This work was supported by FAPESP and CNPq. Thanks are also due to Ms. Patricia Helena Camargo Sabença do Couto, Biochemistry Section, Butantan Institute, and Margareth Trentino Arroyo, Gabriela Kampf Cury, Edson Rocha de Oliveira and Roberto Cabado Modia Jr., Department of Histology and Embryology, University of São Paulo, for inestimable technical support.

PY - 1999/12/18

Y1 - 1999/12/18

N2 - Immunohistochemistry was used to analyze the rat brain distribution of thimet oligopeptidase and neurolysin. Both enzymes appear ubiquitously distributed within the entire rat brain. However, neuronal perikarya and processes stained for neurolysin, while intense nuclear labeling was only observed for thimet oligopeptidase. These data suggest that neurolysin and thimet oligopeptidase, endopeptidases sharing several functional and structural similarities, are present in distinctive intracellular compartments in neuronal cells. Copyright (C) 1999 Elsevier Science B.V.

AB - Immunohistochemistry was used to analyze the rat brain distribution of thimet oligopeptidase and neurolysin. Both enzymes appear ubiquitously distributed within the entire rat brain. However, neuronal perikarya and processes stained for neurolysin, while intense nuclear labeling was only observed for thimet oligopeptidase. These data suggest that neurolysin and thimet oligopeptidase, endopeptidases sharing several functional and structural similarities, are present in distinctive intracellular compartments in neuronal cells. Copyright (C) 1999 Elsevier Science B.V.

KW - Endopeptidase

KW - Intracellular metabolism

KW - Neuropeptide

KW - Nuclear enzyme

KW - Oligopeptidase

KW - Peptide

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U2 - 10.1016/S0006-8993(99)02135-6

DO - 10.1016/S0006-8993(99)02135-6

M3 - Article

C2 - 10642854

AN - SCOPUS:0033378691

SN - 0006-8993

VL - 851

SP - 261

EP - 265

JO - Brain Research

JF - Brain Research

IS - 1-2

ER -

Differential subcellular distribution of neurolysin (EC 3.4.24.16) and thimet oligopeptidase (EC 3.4.24.15) in the rat brain

Abstract

Keywords

ASJC Scopus subject areas

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