Differential regulation of cell cycle characteristics and apoptosis in MMTV-myc and MMTV-ras mouse mammary tumors

Jeff E. Hundley, Steven K. Koester, Dean A. Troyer, Susan G. Hilsenbeck, Rebecca E. Barrington, Jolene J. Windle

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

We have used the MMTV-myc and MMTV-ras transgenic mouse mammary tumor models (T. A. Stewart et al., Cell, 38: 627-637, 1984, and E. Sinn et al., Cell, 49: 465-475, 1987) to evaluate how the c-myc and v-Ha-ras oncogenes influence tumor growth characteristics in vivo. MMTV-myc tumors had much higher levels of spontaneous apoptosis than MMTV-ras tumors, whereas intermediate levels were observed in MMTV-myc/ras tumors. Significant differences in cell cycle characteristics were also observed in tumors from mice of the three genotypes. Tumors from MMTV-myc mice had lower G1 and higher S-phase fractions than MMTV-ras tumors, with intermediate values again observed in the MMTV-myc/ras tumors. Despite these differences, however, tumor growth rates for the different groups were similar. These findings highlight the importance of the balance between cell cycle regulation and cell death in determining the kinetics of tumor growth and indicate that distinct oncogenes can have a profound influence on that balance.

Original languageEnglish (US)
Pages (from-to)600-603
Number of pages4
JournalCancer Research
Volume57
Issue number4
StatePublished - 1997

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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