Differential phosphorylation of cytoplasmic and nuclear variants of simian virus 40 large T antigen encoded by simian virus 40-adenovirus 7 hybrid viruses

K. H. Scheidtmann, J. Schickedanz, G. Walter, R. E. Lanford, J. S. Butel

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

The phosphorylation patterns of cytoplasmic and nuclear forms of simian virus 40 large T antigen encoded by simian virus 40-adenovirus 7 hybrid viruses were analyzed by two-dimensional peptide mapping. The PARA(cT) mutant which encodes a large T antigen defective for nuclear transport was used as a source for cytoplasmic large T antigen. The data suggests that the large T antigen is phosphorylated in a sequential manner at a subset of sites in the cytoplasm and at additional sites in the nucleus.

Original languageEnglish (US)
Pages (from-to)636-640
Number of pages5
JournalJournal of virology
Volume50
Issue number2
DOIs
StatePublished - 1984
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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