Differential phosphorylation of cytoplasmic and nuclear variants of simian virus 40 large T antigen encoded by simian virus 40-adenovirus 7 hybrid viruses

K. H. Scheidtmann, J. Schickedanz, G. Walter, R. E. Lanford, J. S. Butel

    Research output: Contribution to journalArticle

    20 Scopus citations

    Abstract

    The phosphorylation patterns of cytoplasmic and nuclear forms of simian virus 40 large T antigen encoded by simian virus 40-adenovirus 7 hybrid viruses were analyzed by two-dimensional peptide mapping. The PARA(cT) mutant which encodes a large T antigen defective for nuclear transport was used as a source for cytoplasmic large T antigen. The data suggests that the large T antigen is phosphorylated in a sequential manner at a subset of sites in the cytoplasm and at additional sites in the nucleus.

    Original languageEnglish (US)
    Pages (from-to)636-640
    Number of pages5
    JournalJournal of virology
    Volume50
    Issue number2
    DOIs
    StatePublished - 1984

    ASJC Scopus subject areas

    • Microbiology
    • Immunology
    • Insect Science
    • Virology

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