Differential hemodynamic and sympathoadrenal effects of sodium nitroprusside and hydralazine in hypertensive subjects

Alexander M.M. Shepherd, Norman A. Irvine

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

The hemodynamic and sympathoadrenal effects of serial incremental doses of a mixed veno-arte-riolar dilator (intravenous sodium nitroprusside 0.0125-0.50 μg/kg/min) and a pure arteriolar dilator (bolus injections of hydralazine, 0.05-0.3 mg/kg) were compared in 18 subjects with uncomplicated essential hypertension. Blood pressure was reduced to the same extent over approximately the same time with both drugs. Sodium nitroprusside produced significant reduction in cardiac output (9%) and stroke volume (16%) despite an 11% increase in heart rate. Total peripheral resistance did not change. In contrast, hydralazine produced a significant (39%) reduction in peripheral resistance with a compensatory increase in heart rate (19%), stroke volume (20%), and cardiac output (42%). The catecholamine responses to the drugs differed both quantitatively and qualitatively. Administration of both drugs was associated with gradual increases in plasma norepinephrine, but the levels were consistently 40% higher with sodium nitroprusside for the same fall in blood pressure. No consistent change in plasma epinephrine was found with sodium nitroprusside, whereas with hydralazine, the concentration increased gradually after the blood pressure had been reduced by 9 mm Hg. This threshold was independent of the starting blood pressure. These differences in catecholamine response could reflect different patterns of regional sympathetic activation by the low pressure mechanoreceptors (sodium nitroprusside) and by the arterial baroreceptors (hydralazine). Neither drug has an ideal hemodynamic profile, particularly in subjects with cardiac disease, but a balanced combination of the two may produce a favorable hemodynamic profile and optimal hypotensive effect, minimizing the need for large doses of sympathetic inhibitors.

Original languageEnglish (US)
Pages (from-to)527-533
Number of pages7
JournalJournal of Cardiovascular Pharmacology
Volume8
Issue number3
DOIs
StatePublished - May 1986

Keywords

  • Hemodynamics
  • Hypertension
  • Plasma catecholamines
  • Vasodilators

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

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