Abstract
Social cognitive impairment is related to poor social functioning in schizophrenia. This impairment includes both deficits in emotion perception and theory of mind (ToM), and cognitive biases including attributional bias and jumping to conclusions. Oxytocin (OXT) is a hormone that has been implicated in human social behavior, and that has also been associated with regulation of inflammation. In a cross-sectional study involving 60 patients with schizophrenia and 20 healthy controls, we examined associations between OXT and social cognitive capacity and bias. Secondary analyses examined associations between OXT and inflammation. We found significant correlations between OXT and social cognitive bias in the control group and in patients with delusions, but not in patients without delusions. Social cognitive capacity only correlated significantly with OXT in patients with delusions. A correlation between OXT and inflammation was observed only in patients without delusions. Findings suggest that OXT may be implicated in social cognition both in controls and in patients with delusions, but that this association may be blunted in patients without delusions. Inflammation appears to be related to OXT rather independently of social cognition. Future longitudinal and intervention studies with OXT are needed to clarify causality in the identified associations.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 387-392 |
| Number of pages | 6 |
| Journal | Schizophrenia Research |
| Volume | 147 |
| Issue number | 2-3 |
| DOIs | |
| State | Published - Jul 2013 |
Fingerprint
Keywords
- Cytokines/chemokines
- Inflammation
- Oxytocin
- Schizophrenia
- Social cognition
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry
Cite this
Differential correlations between plasma oxytocin and social cognitive capacity and bias in schizophrenia. / Walss-Bass, Consuelo; Fernandes, João M.; Roberts, David; Service, Helena; Velligan, Dawn I.
In: Schizophrenia Research, Vol. 147, No. 2-3, 07.2013, p. 387-392.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Differential correlations between plasma oxytocin and social cognitive capacity and bias in schizophrenia
AU - Walss-Bass, Consuelo
AU - Fernandes, João M.
AU - Roberts, David
AU - Service, Helena
AU - Velligan, Dawn I
PY - 2013/7
Y1 - 2013/7
N2 - Social cognitive impairment is related to poor social functioning in schizophrenia. This impairment includes both deficits in emotion perception and theory of mind (ToM), and cognitive biases including attributional bias and jumping to conclusions. Oxytocin (OXT) is a hormone that has been implicated in human social behavior, and that has also been associated with regulation of inflammation. In a cross-sectional study involving 60 patients with schizophrenia and 20 healthy controls, we examined associations between OXT and social cognitive capacity and bias. Secondary analyses examined associations between OXT and inflammation. We found significant correlations between OXT and social cognitive bias in the control group and in patients with delusions, but not in patients without delusions. Social cognitive capacity only correlated significantly with OXT in patients with delusions. A correlation between OXT and inflammation was observed only in patients without delusions. Findings suggest that OXT may be implicated in social cognition both in controls and in patients with delusions, but that this association may be blunted in patients without delusions. Inflammation appears to be related to OXT rather independently of social cognition. Future longitudinal and intervention studies with OXT are needed to clarify causality in the identified associations.
AB - Social cognitive impairment is related to poor social functioning in schizophrenia. This impairment includes both deficits in emotion perception and theory of mind (ToM), and cognitive biases including attributional bias and jumping to conclusions. Oxytocin (OXT) is a hormone that has been implicated in human social behavior, and that has also been associated with regulation of inflammation. In a cross-sectional study involving 60 patients with schizophrenia and 20 healthy controls, we examined associations between OXT and social cognitive capacity and bias. Secondary analyses examined associations between OXT and inflammation. We found significant correlations between OXT and social cognitive bias in the control group and in patients with delusions, but not in patients without delusions. Social cognitive capacity only correlated significantly with OXT in patients with delusions. A correlation between OXT and inflammation was observed only in patients without delusions. Findings suggest that OXT may be implicated in social cognition both in controls and in patients with delusions, but that this association may be blunted in patients without delusions. Inflammation appears to be related to OXT rather independently of social cognition. Future longitudinal and intervention studies with OXT are needed to clarify causality in the identified associations.
KW - Cytokines/chemokines
KW - Inflammation
KW - Oxytocin
KW - Schizophrenia
KW - Social cognition
UR - http://www.scopus.com/inward/record.url?scp=84878969115&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84878969115&partnerID=8YFLogxK
U2 - 10.1016/j.schres.2013.04.003
DO - 10.1016/j.schres.2013.04.003
M3 - Article
C2 - 23628601
AN - SCOPUS:84878969115
VL - 147
SP - 387
EP - 392
JO - Schizophrenia Research
JF - Schizophrenia Research
SN - 0920-9964
IS - 2-3
ER -