Differential activation of cultured neonatal cardiomyocytes by plasmalemmal versus intracellular G protein-coupled receptor 55

Justine Yu; Elena Deliu; Xue Quian Zhang; Nicholas E. Hoffman; Rhonda L. Carter; Laurel A. Grisanti; G. Cristina Brailoiu; Muniswamy Madesh; Joseph Y. Cheung; Thomas Force; Mary E. Abood; Walter J. Koch; Douglas G. Tilley; Eugen Brailoiu

doi:10.1074/jbc.M113.456178

Differential activation of cultured neonatal cardiomyocytes by plasmalemmal versus intracellular G protein-coupled receptor 55

Justine Yu
, Elena Deliu
, Xue Quian Zhang
, Nicholas E. Hoffman
, Rhonda L. Carter
, Laurel A. Grisanti
, G. Cristina Brailoiu
, Muniswamy Madesh
, Joseph Y. Cheung
, Thomas Force
, Mary E. Abood
, Walter J. Koch
, Douglas G. Tilley
, Eugen Brailoiu

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Background: The LPI-sensitive receptor GPR55 signals through Ca ²⁺. Results: Activation of sarcolemmal versus intracellular GPR55 mobilizes Ca²⁺ from distinct pools and associates with cardiomyocyte depolarization and hyperpolarization, respectively. Conclusion: GPR55 location critically affects LPI-induced modulation of cardiomyocyte function. Significance: We identify GPR55 as a new receptor regulating cardiac function at two cellular sites.

Original language	English (US)
Pages (from-to)	22481-22492
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	288
Issue number	31
DOIs	https://doi.org/10.1074/jbc.M113.456178
State	Published - Aug 2 2013
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Biochemistry
Cell Biology

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Yu, J., Deliu, E., Zhang, X. Q., Hoffman, N. E., Carter, R. L., Grisanti, L. A., Brailoiu, G. C., Madesh, M., Cheung, J. Y., Force, T., Abood, M. E., Koch, W. J., Tilley, D. G., & Brailoiu, E. (2013). Differential activation of cultured neonatal cardiomyocytes by plasmalemmal versus intracellular G protein-coupled receptor 55. Journal of Biological Chemistry, 288(31), 22481-22492. https://doi.org/10.1074/jbc.M113.456178

Yu, J, Deliu, E, Zhang, XQ, Hoffman, NE, Carter, RL, Grisanti, LA, Brailoiu, GC, Madesh, M, Cheung, JY, Force, T, Abood, ME, Koch, WJ, Tilley, DG & Brailoiu, E 2013, 'Differential activation of cultured neonatal cardiomyocytes by plasmalemmal versus intracellular G protein-coupled receptor 55', Journal of Biological Chemistry, vol. 288, no. 31, pp. 22481-22492. https://doi.org/10.1074/jbc.M113.456178

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title = "Differential activation of cultured neonatal cardiomyocytes by plasmalemmal versus intracellular G protein-coupled receptor 55",

abstract = "Background: The LPI-sensitive receptor GPR55 signals through Ca 2+. Results: Activation of sarcolemmal versus intracellular GPR55 mobilizes Ca2+ from distinct pools and associates with cardiomyocyte depolarization and hyperpolarization, respectively. Conclusion: GPR55 location critically affects LPI-induced modulation of cardiomyocyte function. Significance: We identify GPR55 as a new receptor regulating cardiac function at two cellular sites.",

author = "Justine Yu and Elena Deliu and Zhang, \{Xue Quian\} and Hoffman, \{Nicholas E.\} and Carter, \{Rhonda L.\} and Grisanti, \{Laurel A.\} and Brailoiu, \{G. Cristina\} and Muniswamy Madesh and Cheung, \{Joseph Y.\} and Thomas Force and Abood, \{Mary E.\} and Koch, \{Walter J.\} and Tilley, \{Douglas G.\} and Eugen Brailoiu",

year = "2013",

month = aug,

day = "2",

doi = "10.1074/jbc.M113.456178",

language = "English (US)",

volume = "288",

pages = "22481--22492",

journal = "Journal of Biological Chemistry",

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T1 - Differential activation of cultured neonatal cardiomyocytes by plasmalemmal versus intracellular G protein-coupled receptor 55

AU - Yu, Justine

AU - Deliu, Elena

AU - Zhang, Xue Quian

AU - Hoffman, Nicholas E.

AU - Carter, Rhonda L.

AU - Grisanti, Laurel A.

AU - Brailoiu, G. Cristina

AU - Madesh, Muniswamy

AU - Cheung, Joseph Y.

AU - Force, Thomas

AU - Abood, Mary E.

AU - Koch, Walter J.

AU - Tilley, Douglas G.

AU - Brailoiu, Eugen

PY - 2013/8/2

Y1 - 2013/8/2

N2 - Background: The LPI-sensitive receptor GPR55 signals through Ca 2+. Results: Activation of sarcolemmal versus intracellular GPR55 mobilizes Ca2+ from distinct pools and associates with cardiomyocyte depolarization and hyperpolarization, respectively. Conclusion: GPR55 location critically affects LPI-induced modulation of cardiomyocyte function. Significance: We identify GPR55 as a new receptor regulating cardiac function at two cellular sites.

AB - Background: The LPI-sensitive receptor GPR55 signals through Ca 2+. Results: Activation of sarcolemmal versus intracellular GPR55 mobilizes Ca2+ from distinct pools and associates with cardiomyocyte depolarization and hyperpolarization, respectively. Conclusion: GPR55 location critically affects LPI-induced modulation of cardiomyocyte function. Significance: We identify GPR55 as a new receptor regulating cardiac function at two cellular sites.

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AN - SCOPUS:84881253920

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SP - 22481

EP - 22492

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 31

ER -

Differential activation of cultured neonatal cardiomyocytes by plasmalemmal versus intracellular G protein-coupled receptor 55

Abstract

ASJC Scopus subject areas

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