Differential activation of cultured neonatal cardiomyocytes by plasmalemmal versus intracellular G protein-coupled receptor 55

Justine Yu, Elena Deliu, Xue Quian Zhang, Nicholas E. Hoffman, Rhonda L. Carter, Laurel A. Grisanti, G. Cristina Brailoiu, Muniswamy Madesh, Joseph Y. Cheung, Thomas Force, Mary E. Abood, Walter J. Koch, Douglas G. Tilley, Eugen Brailoiu

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Background: The LPI-sensitive receptor GPR55 signals through Ca 2+. Results: Activation of sarcolemmal versus intracellular GPR55 mobilizes Ca2+ from distinct pools and associates with cardiomyocyte depolarization and hyperpolarization, respectively. Conclusion: GPR55 location critically affects LPI-induced modulation of cardiomyocyte function. Significance: We identify GPR55 as a new receptor regulating cardiac function at two cellular sites.

Original languageEnglish (US)
Pages (from-to)22481-22492
Number of pages12
JournalJournal of Biological Chemistry
Volume288
Issue number31
DOIs
StatePublished - Aug 2 2013
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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