Differential activation of cultured neonatal cardiomyocytes by plasmalemmal versus intracellular G protein-coupled receptor 55

Justine Yu; Elena Deliu; Xue Quian Zhang; Nicholas E. Hoffman; Rhonda L. Carter; Laurel A. Grisanti; G. Cristina Brailoiu; Muniswamy Madesh; Joseph Y. Cheung; Thomas Force; Mary E. Abood; Walter J. Koch; Douglas G. Tilley; Eugen Brailoiu

doi:10.1074/jbc.M113.456178

Differential activation of cultured neonatal cardiomyocytes by plasmalemmal versus intracellular G protein-coupled receptor 55

Justine Yu, Elena Deliu, Xue Quian Zhang, Nicholas E. Hoffman, Rhonda L. Carter, Laurel A. Grisanti, G. Cristina Brailoiu, Muniswamy Madesh, Joseph Y. Cheung, Thomas Force, Mary E. Abood, Walter J. Koch, Douglas G. Tilley, Eugen Brailoiu

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Background: The LPI-sensitive receptor GPR55 signals through Ca ²⁺. Results: Activation of sarcolemmal versus intracellular GPR55 mobilizes Ca²⁺ from distinct pools and associates with cardiomyocyte depolarization and hyperpolarization, respectively. Conclusion: GPR55 location critically affects LPI-induced modulation of cardiomyocyte function. Significance: We identify GPR55 as a new receptor regulating cardiac function at two cellular sites.

Original language	English (US)
Pages (from-to)	22481-22492
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	288
Issue number	31
DOIs	https://doi.org/10.1074/jbc.M113.456178
State	Published - Aug 2 2013
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Biochemistry
Cell Biology

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Yu, J., Deliu, E., Zhang, X. Q., Hoffman, N. E., Carter, R. L., Grisanti, L. A., Brailoiu, G. C., Madesh, M., Cheung, J. Y., Force, T., Abood, M. E., Koch, W. J., Tilley, D. G., & Brailoiu, E. (2013). Differential activation of cultured neonatal cardiomyocytes by plasmalemmal versus intracellular G protein-coupled receptor 55. Journal of Biological Chemistry, 288(31), 22481-22492. https://doi.org/10.1074/jbc.M113.456178

Yu, J, Deliu, E, Zhang, XQ, Hoffman, NE, Carter, RL, Grisanti, LA, Brailoiu, GC, Madesh, M, Cheung, JY, Force, T, Abood, ME, Koch, WJ, Tilley, DG & Brailoiu, E 2013, 'Differential activation of cultured neonatal cardiomyocytes by plasmalemmal versus intracellular G protein-coupled receptor 55', Journal of Biological Chemistry, vol. 288, no. 31, pp. 22481-22492. https://doi.org/10.1074/jbc.M113.456178

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title = "Differential activation of cultured neonatal cardiomyocytes by plasmalemmal versus intracellular G protein-coupled receptor 55",

abstract = "Background: The LPI-sensitive receptor GPR55 signals through Ca 2+. Results: Activation of sarcolemmal versus intracellular GPR55 mobilizes Ca2+ from distinct pools and associates with cardiomyocyte depolarization and hyperpolarization, respectively. Conclusion: GPR55 location critically affects LPI-induced modulation of cardiomyocyte function. Significance: We identify GPR55 as a new receptor regulating cardiac function at two cellular sites.",

author = "Justine Yu and Elena Deliu and Zhang, {Xue Quian} and Hoffman, {Nicholas E.} and Carter, {Rhonda L.} and Grisanti, {Laurel A.} and Brailoiu, {G. Cristina} and Muniswamy Madesh and Cheung, {Joseph Y.} and Thomas Force and Abood, {Mary E.} and Koch, {Walter J.} and Tilley, {Douglas G.} and Eugen Brailoiu",

year = "2013",

month = aug,

day = "2",

doi = "10.1074/jbc.M113.456178",

language = "English (US)",

volume = "288",

pages = "22481--22492",

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T1 - Differential activation of cultured neonatal cardiomyocytes by plasmalemmal versus intracellular G protein-coupled receptor 55

AU - Yu, Justine

AU - Deliu, Elena

AU - Zhang, Xue Quian

AU - Hoffman, Nicholas E.

AU - Carter, Rhonda L.

AU - Grisanti, Laurel A.

AU - Brailoiu, G. Cristina

AU - Madesh, Muniswamy

AU - Cheung, Joseph Y.

AU - Force, Thomas

AU - Abood, Mary E.

AU - Koch, Walter J.

AU - Tilley, Douglas G.

AU - Brailoiu, Eugen

PY - 2013/8/2

Y1 - 2013/8/2

N2 - Background: The LPI-sensitive receptor GPR55 signals through Ca 2+. Results: Activation of sarcolemmal versus intracellular GPR55 mobilizes Ca2+ from distinct pools and associates with cardiomyocyte depolarization and hyperpolarization, respectively. Conclusion: GPR55 location critically affects LPI-induced modulation of cardiomyocyte function. Significance: We identify GPR55 as a new receptor regulating cardiac function at two cellular sites.

AB - Background: The LPI-sensitive receptor GPR55 signals through Ca 2+. Results: Activation of sarcolemmal versus intracellular GPR55 mobilizes Ca2+ from distinct pools and associates with cardiomyocyte depolarization and hyperpolarization, respectively. Conclusion: GPR55 location critically affects LPI-induced modulation of cardiomyocyte function. Significance: We identify GPR55 as a new receptor regulating cardiac function at two cellular sites.

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Differential activation of cultured neonatal cardiomyocytes by plasmalemmal versus intracellular G protein-coupled receptor 55

Abstract

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