Different concentration of human cord blood HMGB1 according to delivery and labour: A pilot study

G. D'Angelo, L. Marseglia, R. Granese, A. Di Benedetto, A. Giacobbe, P. Impellizzeri, A. Alibrandi, E. Ferro, A. Palmara, S. Manti, T. Arrigo, C. Salpietro, G. Buonocore, Russel J Reiter, E. Gitto

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: Oxidative stress is involved in several maternal conditions characterized both by an increase in free radicals synthesis and a parallel decrease in the antioxidant activity. Parturition induces considerable oxidative stress and many inflammatory mediators, among which HMGB1, are involved from the beginning of pregnancy to the birth of the infant. We evaluated serum cord blood HMGB1 levels in a population of neonates to investigate correlation with mode of delivery, as well as the influence of labour. Setting and patients: The study subjects were 325 neonates delivered at University Hospital “G. Martino” of Messina over an 18-month period. Following cord separation, venous blood sampling was performed on umbelical cords. Results: In the cord venous blood, we found HMGB1 values significantly more elevated in spontaneous vaginal group when compared to elective or emergency caesarean section group. Regarding labour, umbilical cord venous blood HMGB1 levels were significantly higher in the spontaneous and induced labour group, compared to non-labouring women. Conclusion: These results could highlight a possible role of HMGB1 during birth time related to mode of delivery and labour.

Original languageEnglish (US)
Pages (from-to)53-56
Number of pages4
JournalCytokine
Volume108
DOIs
StatePublished - Aug 1 2018

Fingerprint

HMGB1 Protein
Fetal Blood
Blood
Personnel
Oxidative stress
Parturition
Oxidative Stress
Newborn Infant
Induced Labor
Cesarean Section
Free Radicals
Emergencies
Antioxidants
Mothers
Sampling
Pregnancy
Serum
Population

Keywords

  • Cord blood
  • Delivery
  • High Mobility Group Box 1
  • Labour
  • Newborn

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Hematology
  • Molecular Biology

Cite this

D'Angelo, G., Marseglia, L., Granese, R., Di Benedetto, A., Giacobbe, A., Impellizzeri, P., ... Gitto, E. (2018). Different concentration of human cord blood HMGB1 according to delivery and labour: A pilot study. Cytokine, 108, 53-56. https://doi.org/10.1016/j.cyto.2018.03.019

Different concentration of human cord blood HMGB1 according to delivery and labour : A pilot study. / D'Angelo, G.; Marseglia, L.; Granese, R.; Di Benedetto, A.; Giacobbe, A.; Impellizzeri, P.; Alibrandi, A.; Ferro, E.; Palmara, A.; Manti, S.; Arrigo, T.; Salpietro, C.; Buonocore, G.; Reiter, Russel J; Gitto, E.

In: Cytokine, Vol. 108, 01.08.2018, p. 53-56.

Research output: Contribution to journalArticle

D'Angelo, G, Marseglia, L, Granese, R, Di Benedetto, A, Giacobbe, A, Impellizzeri, P, Alibrandi, A, Ferro, E, Palmara, A, Manti, S, Arrigo, T, Salpietro, C, Buonocore, G, Reiter, RJ & Gitto, E 2018, 'Different concentration of human cord blood HMGB1 according to delivery and labour: A pilot study', Cytokine, vol. 108, pp. 53-56. https://doi.org/10.1016/j.cyto.2018.03.019
D'Angelo G, Marseglia L, Granese R, Di Benedetto A, Giacobbe A, Impellizzeri P et al. Different concentration of human cord blood HMGB1 according to delivery and labour: A pilot study. Cytokine. 2018 Aug 1;108:53-56. https://doi.org/10.1016/j.cyto.2018.03.019
D'Angelo, G. ; Marseglia, L. ; Granese, R. ; Di Benedetto, A. ; Giacobbe, A. ; Impellizzeri, P. ; Alibrandi, A. ; Ferro, E. ; Palmara, A. ; Manti, S. ; Arrigo, T. ; Salpietro, C. ; Buonocore, G. ; Reiter, Russel J ; Gitto, E. / Different concentration of human cord blood HMGB1 according to delivery and labour : A pilot study. In: Cytokine. 2018 ; Vol. 108. pp. 53-56.
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