TY - JOUR
T1 - Differences in insulin action and secretion, plasma lipids and blood pressure levels between impaired fasting glucose and impaired glucose tolerance in Japanese subjects
AU - Miyazaki, Yoshinori
AU - Akasaka, Hiroshi
AU - Ohnishi, Hirofumi
AU - Saitoh, Shigeyuki
AU - DeFronzo, Ralph A.
AU - Shimamoto, Kazuaki
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2008
Y1 - 2008
N2 - We examined insulin action/secretion and cardiovascular disease risk factors in Japanese subjects with impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT) who were not taking any medications known to affect glucose tolerance, blood pressure (BP) or plasma lipids (PLs). A total of 1,399 subjects received measurements of anthropometry, BP, PLs, and plasma glucose/insulin concentrations during 75 goral glucose tolerance test (OGTT). According to 2003 American Diabetes Association criteria, subjects were classified as having normal fasting glucose (NFG)/normal glucose tolerance (NGT) (n=1,173), IFG (n=128), IGT (n=55), and IFG/IGT (n=43). Insulin action was calculated using the HOMA-R (index of hepatic insulin resistance) and Matsuda index (reflects whole body insulin sensitivity). The ratio of the incremental area under the curve of insulin to that of glucose during OGTT (ΔAUCPI/ΔAUCPG) was used as an index of β-cell function. HOMA-R was higher in IFG (2.3±0.1) and IFG/IGT (2.5±0.2) than in NFG/NGT (1.8±0.03). The Matsuda index was lower in IFG (6.5±0.3), IGT (5.4±0.4) and IFG/IGT (5.1±0.5) than in NFG/NGT (9.6±0.2). ΔAUCPI/ΔAUCPG was lower in IGT (0.6±0.05) and IFG/IGT (0.5±0.05) than in IFG (1.4±0.12) or NFG/NGT (1.2±0.03). Mean BP was higher in IGT (100±1.7 mmHg) than in NFG/NGT (91±0.3) or IFG (95±1.1). The plasma triglyceride level was higher in IGT (155±14 mg/dL) and IGT/IFG (173±12) than in IFG (132±7) or NFG/NGT (122±2). In conclusion, 1) whole body insulin sensitivity is decreased in IFG and IGT, with a greater reduction in IGT, 2) hepatic insulin resistance and preserved β-cell function are characteristics of IFG, and 3) higher BP and triglyceride levels are observed in IGT. IGT is more closely associated with risk factors for cardiovascular disease than is IFG.
AB - We examined insulin action/secretion and cardiovascular disease risk factors in Japanese subjects with impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT) who were not taking any medications known to affect glucose tolerance, blood pressure (BP) or plasma lipids (PLs). A total of 1,399 subjects received measurements of anthropometry, BP, PLs, and plasma glucose/insulin concentrations during 75 goral glucose tolerance test (OGTT). According to 2003 American Diabetes Association criteria, subjects were classified as having normal fasting glucose (NFG)/normal glucose tolerance (NGT) (n=1,173), IFG (n=128), IGT (n=55), and IFG/IGT (n=43). Insulin action was calculated using the HOMA-R (index of hepatic insulin resistance) and Matsuda index (reflects whole body insulin sensitivity). The ratio of the incremental area under the curve of insulin to that of glucose during OGTT (ΔAUCPI/ΔAUCPG) was used as an index of β-cell function. HOMA-R was higher in IFG (2.3±0.1) and IFG/IGT (2.5±0.2) than in NFG/NGT (1.8±0.03). The Matsuda index was lower in IFG (6.5±0.3), IGT (5.4±0.4) and IFG/IGT (5.1±0.5) than in NFG/NGT (9.6±0.2). ΔAUCPI/ΔAUCPG was lower in IGT (0.6±0.05) and IFG/IGT (0.5±0.05) than in IFG (1.4±0.12) or NFG/NGT (1.2±0.03). Mean BP was higher in IGT (100±1.7 mmHg) than in NFG/NGT (91±0.3) or IFG (95±1.1). The plasma triglyceride level was higher in IGT (155±14 mg/dL) and IGT/IFG (173±12) than in IFG (132±7) or NFG/NGT (122±2). In conclusion, 1) whole body insulin sensitivity is decreased in IFG and IGT, with a greater reduction in IGT, 2) hepatic insulin resistance and preserved β-cell function are characteristics of IFG, and 3) higher BP and triglyceride levels are observed in IGT. IGT is more closely associated with risk factors for cardiovascular disease than is IFG.
KW - Cardiovascular disease risk factors
KW - Impaired fasting glucose
KW - Impaired glucose tolerance
UR - http://www.scopus.com/inward/record.url?scp=55449106221&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=55449106221&partnerID=8YFLogxK
U2 - 10.1291/hypres.31.1357
DO - 10.1291/hypres.31.1357
M3 - Article
C2 - 18957806
AN - SCOPUS:55449106221
SN - 0916-9636
VL - 31
SP - 1357
EP - 1363
JO - Hypertension Research
JF - Hypertension Research
IS - 7
ER -