TY - JOUR
T1 - Differences between liver gap junction protein and lens MIP 26 from rat
T2 - Implications for tissue specificity of gap junctions
AU - Nicholson, Bruce J.
AU - Takemoto, Larry J.
AU - Hunkapiller, Michael W.
AU - Hood, Leroy E.
AU - Revel, Jean Paul
N1 - Funding Information:
We wish to thank Drs. Barbara Yancey and David Meyer for fruitful feedback throughout this project, and Messrs. Les Grim and Jeff Hansen, whose technical expertise was central to much of this work. Dr. Daniel Gros has contributed greatly to our understanding of heart gap junctions. The research was supported by a research grant from the Biomedical Research Support Program of the National Institutes of Health, and by grants from the National Eye Institute and the National Institutes of Health to L. J. T., as well as by the Ross Foundation fellowship.
PY - 1983/3
Y1 - 1983/3
N2 - Liver gap junctions and gap-junction-like structures from eye lenses are each comprised of a single major protein (Mr 28,000 and 26,000, respectively). These proteins display different two-dimensional peptide fingerprints, distinct amino acid compositions, nonhomologous N-terminal amino acid sequences and different sensitivities to proteases when part of the intact junction. However, the junctional protein of each tissue is well conserved between species, as demonstrated previously for lens and now for liver in several mammalian species. The possibility of tissue-specific gap junction proteins is discussed in the light of data suggesting that rat heart gap junctions are comprised of yet a third protein.
AB - Liver gap junctions and gap-junction-like structures from eye lenses are each comprised of a single major protein (Mr 28,000 and 26,000, respectively). These proteins display different two-dimensional peptide fingerprints, distinct amino acid compositions, nonhomologous N-terminal amino acid sequences and different sensitivities to proteases when part of the intact junction. However, the junctional protein of each tissue is well conserved between species, as demonstrated previously for lens and now for liver in several mammalian species. The possibility of tissue-specific gap junction proteins is discussed in the light of data suggesting that rat heart gap junctions are comprised of yet a third protein.
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U2 - 10.1016/0092-8674(83)90081-8
DO - 10.1016/0092-8674(83)90081-8
M3 - Article
C2 - 6299583
AN - SCOPUS:0020560348
VL - 32
SP - 967
EP - 978
JO - Cell
JF - Cell
SN - 0092-8674
IS - 3
ER -