Differences between liver gap junction protein and lens MIP 26 from rat: Implications for tissue specificity of gap junctions

Bruce J Nicholson, Larry J. Takemoto, Michael W. Hunkapiller, Leroy E. Hood, Jean Paul Revel

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Liver gap junctions and gap-junction-like structures from eye lenses are each comprised of a single major protein (Mr 28,000 and 26,000, respectively). These proteins display different two-dimensional peptide fingerprints, distinct amino acid compositions, nonhomologous N-terminal amino acid sequences and different sensitivities to proteases when part of the intact junction. However, the junctional protein of each tissue is well conserved between species, as demonstrated previously for lens and now for liver in several mammalian species. The possibility of tissue-specific gap junction proteins is discussed in the light of data suggesting that rat heart gap junctions are comprised of yet a third protein.

Original languageEnglish (US)
Pages (from-to)967-978
Number of pages12
JournalCell
Volume32
Issue number3
DOIs
StatePublished - 1983
Externally publishedYes

Fingerprint

Organ Specificity
Connexins
Gap Junctions
Liver
Lenses
Rats
Tissue
Proteins
Amino Acids
Crystalline Lens
Peptide Mapping
Amino Acid Sequence
Peptide Hydrolases
Peptides
Chemical analysis

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Medicine(all)

Cite this

Differences between liver gap junction protein and lens MIP 26 from rat : Implications for tissue specificity of gap junctions. / Nicholson, Bruce J; Takemoto, Larry J.; Hunkapiller, Michael W.; Hood, Leroy E.; Revel, Jean Paul.

In: Cell, Vol. 32, No. 3, 1983, p. 967-978.

Research output: Contribution to journalArticle

Nicholson, Bruce J ; Takemoto, Larry J. ; Hunkapiller, Michael W. ; Hood, Leroy E. ; Revel, Jean Paul. / Differences between liver gap junction protein and lens MIP 26 from rat : Implications for tissue specificity of gap junctions. In: Cell. 1983 ; Vol. 32, No. 3. pp. 967-978.
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