Dietary restrictions early and late effects on the nephropathy of the NZB X NZW mouse

P. S. Friend, G. Fernandes, R. A. Good, A. F. Michael, E. J. Yunis

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

NZB x NZW F 1 mice initiated on calorie restriction at weaning or at 4 to 5 months of age or initiated on moderate protein restriction at weaning, were afforded significant protection from the development of immune nephritis. Whereas animals on normal calorie intake demonstrated deposition of immune reactants in a glomerular basement membrane-oriented pattern, those on either protein or calorie restriction exhibited mesangial confinement of immunoglobulins and complement. Associated with these divergent patterns of immune deposition, mice on normal calorie intake evidenced extensive cellular proliferation and glomerular sclerosis while dietary restricted mice demonstrated virtually no hyalinization and only mild cellular proliferation. Autoantibody formation of calorie-restricted animals was significantly decreased compared to mice fed a normal diet. Thus, moderate dietary restriction may serve as either prophylactic or effective therapeutic approach to ongoing autoimmune disease.

Original languageEnglish (US)
Pages (from-to)629-632
Number of pages4
JournalLaboratory Investigation
Volume38
Issue number6
StatePublished - 1978
Externally publishedYes

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Weaning
Cell Proliferation
Glomerular Basement Membrane
Nephritis
Sclerosis
Autoantibodies
Autoimmune Diseases
Immunoglobulins
Proteins
Diet
Therapeutics

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Friend, P. S., Fernandes, G., Good, R. A., Michael, A. F., & Yunis, E. J. (1978). Dietary restrictions early and late effects on the nephropathy of the NZB X NZW mouse. Laboratory Investigation, 38(6), 629-632.

Dietary restrictions early and late effects on the nephropathy of the NZB X NZW mouse. / Friend, P. S.; Fernandes, G.; Good, R. A.; Michael, A. F.; Yunis, E. J.

In: Laboratory Investigation, Vol. 38, No. 6, 1978, p. 629-632.

Research output: Contribution to journalArticle

Friend, PS, Fernandes, G, Good, RA, Michael, AF & Yunis, EJ 1978, 'Dietary restrictions early and late effects on the nephropathy of the NZB X NZW mouse', Laboratory Investigation, vol. 38, no. 6, pp. 629-632.
Friend PS, Fernandes G, Good RA, Michael AF, Yunis EJ. Dietary restrictions early and late effects on the nephropathy of the NZB X NZW mouse. Laboratory Investigation. 1978;38(6):629-632.
Friend, P. S. ; Fernandes, G. ; Good, R. A. ; Michael, A. F. ; Yunis, E. J. / Dietary restrictions early and late effects on the nephropathy of the NZB X NZW mouse. In: Laboratory Investigation. 1978 ; Vol. 38, No. 6. pp. 629-632.
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