Dietary restrictions early and late effects on the nephropathy of the NZB X NZW mouse

P. S. Friend, G. Fernandes, R. A. Good, A. F. Michael, E. J. Yunis

Research output: Contribution to journalArticlepeer-review

63 Scopus citations

Abstract

NZB x NZW F 1 mice initiated on calorie restriction at weaning or at 4 to 5 months of age or initiated on moderate protein restriction at weaning, were afforded significant protection from the development of immune nephritis. Whereas animals on normal calorie intake demonstrated deposition of immune reactants in a glomerular basement membrane-oriented pattern, those on either protein or calorie restriction exhibited mesangial confinement of immunoglobulins and complement. Associated with these divergent patterns of immune deposition, mice on normal calorie intake evidenced extensive cellular proliferation and glomerular sclerosis while dietary restricted mice demonstrated virtually no hyalinization and only mild cellular proliferation. Autoantibody formation of calorie-restricted animals was significantly decreased compared to mice fed a normal diet. Thus, moderate dietary restriction may serve as either prophylactic or effective therapeutic approach to ongoing autoimmune disease.

Original languageEnglish (US)
Pages (from-to)629-632
Number of pages4
JournalLaboratory Investigation
Volume38
Issue number6
StatePublished - Dec 1 1978

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology

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