Dietary restriction retards age-related decrease in cell population of rat corneal endothelium

M. J. Nadakavukaren, K. L. Fitch, A. Richardson

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The surface areas of corneal endothelial cells from 12- and 18-month-old male Fischer 344 rats fed ad libitum or a calorie-restricted diet were compared. The rats fed the restricted diet in both age groups showed a statistically significant reduction in the mean cell area of the corneal endothelium. The data indicate that dietary restriction retarded the age-related endothelial cell loss and the subsequent enlargement that takes place to compensate for cell loss. This is the first report to suggest that dietary restriction retards age-related cell loss.

Original languageEnglish (US)
Pages (from-to)98-101
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Volume184
Issue number1
StatePublished - 1987
Externally publishedYes

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Corneal Endothelium
Rats
Endothelial cells
Cells
Nutrition
Endothelial Cells
Population
Diet
Inbred F344 Rats
Age Groups

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Dietary restriction retards age-related decrease in cell population of rat corneal endothelium. / Nadakavukaren, M. J.; Fitch, K. L.; Richardson, A.

In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 184, No. 1, 1987, p. 98-101.

Research output: Contribution to journalArticle

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