TY - JOUR
T1 - Dietary Restriction Retards Age-Related Decrease in Cell Population of Rat Corneal Endothelium
AU - Nadakavukaren, Mathew J.
AU - Fitch, Kenneth L.
AU - Richardson, Arlan
PY - 1987/1
Y1 - 1987/1
N2 - The surface areas of corneal endothelial cells from 12- and 18-month-old male Fischer 344 rats fed ad libitum or a calorie-restricted diet were compared. The rats fed the restricted diet in both age groups showed a statistically significant reduction in the mean cell area of the corneal endothelium. The data indicate that dietary restriction retarded the age-related endothelial cell loss and the subsequent enlargement that takes place to compensate for cell loss. This is the first report to suggest that dietary restriction retards age-related cell loss.
AB - The surface areas of corneal endothelial cells from 12- and 18-month-old male Fischer 344 rats fed ad libitum or a calorie-restricted diet were compared. The rats fed the restricted diet in both age groups showed a statistically significant reduction in the mean cell area of the corneal endothelium. The data indicate that dietary restriction retarded the age-related endothelial cell loss and the subsequent enlargement that takes place to compensate for cell loss. This is the first report to suggest that dietary restriction retards age-related cell loss.
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U2 - 10.3181/00379727-184-42451
DO - 10.3181/00379727-184-42451
M3 - Article
C2 - 3797430
AN - SCOPUS:0023125864
SN - 1535-3702
VL - 184
SP - 98
EP - 101
JO - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)
JF - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)
IS - 1
ER -