Dietary Restriction Retards Age-Related Decrease in Cell Population of Rat Corneal Endothelium

Mathew J. Nadakavukaren, Kenneth L. Fitch, Arlan Richardson

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The surface areas of corneal endothelial cells from 12- and 18-month-old male Fischer 344 rats fed ad libitum or a calorie-restricted diet were compared. The rats fed the restricted diet in both age groups showed a statistically significant reduction in the mean cell area of the corneal endothelium. The data indicate that dietary restriction retarded the age-related endothelial cell loss and the subsequent enlargement that takes place to compensate for cell loss. This is the first report to suggest that dietary restriction retards age-related cell loss.

Original languageEnglish (US)
Pages (from-to)98-101
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Volume184
Issue number1
DOIs
StatePublished - Jan 1987

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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