Dietary patterns, supplement use, and the risk of symptomatic benign prostatic hyperplasia: Results from the Prostate Cancer Prevention Trial

Alan R. Kristal, Kathryn B. Arnold, Jeannette M. Schenk, Marian L. Neuhouser, Phyllis Goodman, David F. Penson, Ian M. Thompson

Research output: Contribution to journalArticle

109 Citations (Scopus)

Abstract

This study examined dietary risk factors for incident benign prostatic hyperplasia (BPH) in 4,770 Prostate Cancer Prevention Trial (1994-2003) placebo-arm participants who were free of BPH at baseline. BPH was assessed over 7 years and was defined as medical or surgical treatment or repeated elevation (>14) on the International Prostate Symptom Score questionnaire. Diet, alcohol, and supplement use were assessed by use of a food frequency questionnaire. There were 876 incident BPH cases (33.6/1,000 person-years). The hazard ratios for the contrasts of the highest to lowest quintiles increased 31% for total fat and 27% for polyunsaturated fat and decreased 15% for protein (all ptrend < 0.05). The risk was significantly lower in high consumers of alcoholic beverages (0 vs. ≥2/day: hazard ratio (HR) = 0.67) and vegetables (<1 vs. ≥4/day: HR = 0.68) and higher in daily (vs. <1/week) consumers of red meat (HR = 1.38). There were no associations of supplemental antioxidants with risk, and there was weak evidence for associations of lycopene, zinc, and supplemental vitamin D with reduced risk. A diet low in fat and red meat and high in protein and vegetables, as well as regular alcohol consumption, may reduce the risk of symptomatic BPH.

Original languageEnglish (US)
Pages (from-to)925-934
Number of pages10
JournalAmerican Journal of Epidemiology
Volume167
Issue number8
DOIs
StatePublished - Apr 2008

Fingerprint

Prostatic Hyperplasia
Dietary Supplements
Prostatic Neoplasms
Fats
Vegetable Proteins
Diet
Alcoholic Beverages
Vitamin D
Alcohol Drinking
Vegetables
Zinc
Prostate
Antioxidants
Placebos
Alcohols
Food
Proteins
Surveys and Questionnaires
Red Meat

Keywords

  • Alcohol drinking
  • Diet
  • Dietary supplements
  • Prostatic hyperplasia

ASJC Scopus subject areas

  • Epidemiology

Cite this

Kristal, A. R., Arnold, K. B., Schenk, J. M., Neuhouser, M. L., Goodman, P., Penson, D. F., & Thompson, I. M. (2008). Dietary patterns, supplement use, and the risk of symptomatic benign prostatic hyperplasia: Results from the Prostate Cancer Prevention Trial. American Journal of Epidemiology, 167(8), 925-934. https://doi.org/10.1093/aje/kwm389

Dietary patterns, supplement use, and the risk of symptomatic benign prostatic hyperplasia : Results from the Prostate Cancer Prevention Trial. / Kristal, Alan R.; Arnold, Kathryn B.; Schenk, Jeannette M.; Neuhouser, Marian L.; Goodman, Phyllis; Penson, David F.; Thompson, Ian M.

In: American Journal of Epidemiology, Vol. 167, No. 8, 04.2008, p. 925-934.

Research output: Contribution to journalArticle

Kristal, Alan R. ; Arnold, Kathryn B. ; Schenk, Jeannette M. ; Neuhouser, Marian L. ; Goodman, Phyllis ; Penson, David F. ; Thompson, Ian M. / Dietary patterns, supplement use, and the risk of symptomatic benign prostatic hyperplasia : Results from the Prostate Cancer Prevention Trial. In: American Journal of Epidemiology. 2008 ; Vol. 167, No. 8. pp. 925-934.
@article{7bc66495786e4c8dbc3def9858124a1f,
title = "Dietary patterns, supplement use, and the risk of symptomatic benign prostatic hyperplasia: Results from the Prostate Cancer Prevention Trial",
abstract = "This study examined dietary risk factors for incident benign prostatic hyperplasia (BPH) in 4,770 Prostate Cancer Prevention Trial (1994-2003) placebo-arm participants who were free of BPH at baseline. BPH was assessed over 7 years and was defined as medical or surgical treatment or repeated elevation (>14) on the International Prostate Symptom Score questionnaire. Diet, alcohol, and supplement use were assessed by use of a food frequency questionnaire. There were 876 incident BPH cases (33.6/1,000 person-years). The hazard ratios for the contrasts of the highest to lowest quintiles increased 31{\%} for total fat and 27{\%} for polyunsaturated fat and decreased 15{\%} for protein (all ptrend < 0.05). The risk was significantly lower in high consumers of alcoholic beverages (0 vs. ≥2/day: hazard ratio (HR) = 0.67) and vegetables (<1 vs. ≥4/day: HR = 0.68) and higher in daily (vs. <1/week) consumers of red meat (HR = 1.38). There were no associations of supplemental antioxidants with risk, and there was weak evidence for associations of lycopene, zinc, and supplemental vitamin D with reduced risk. A diet low in fat and red meat and high in protein and vegetables, as well as regular alcohol consumption, may reduce the risk of symptomatic BPH.",
keywords = "Alcohol drinking, Diet, Dietary supplements, Prostatic hyperplasia",
author = "Kristal, {Alan R.} and Arnold, {Kathryn B.} and Schenk, {Jeannette M.} and Neuhouser, {Marian L.} and Phyllis Goodman and Penson, {David F.} and Thompson, {Ian M.}",
year = "2008",
month = "4",
doi = "10.1093/aje/kwm389",
language = "English (US)",
volume = "167",
pages = "925--934",
journal = "American Journal of Epidemiology",
issn = "0002-9262",
publisher = "Oxford University Press",
number = "8",

}

TY - JOUR

T1 - Dietary patterns, supplement use, and the risk of symptomatic benign prostatic hyperplasia

T2 - Results from the Prostate Cancer Prevention Trial

AU - Kristal, Alan R.

AU - Arnold, Kathryn B.

AU - Schenk, Jeannette M.

AU - Neuhouser, Marian L.

AU - Goodman, Phyllis

AU - Penson, David F.

AU - Thompson, Ian M.

PY - 2008/4

Y1 - 2008/4

N2 - This study examined dietary risk factors for incident benign prostatic hyperplasia (BPH) in 4,770 Prostate Cancer Prevention Trial (1994-2003) placebo-arm participants who were free of BPH at baseline. BPH was assessed over 7 years and was defined as medical or surgical treatment or repeated elevation (>14) on the International Prostate Symptom Score questionnaire. Diet, alcohol, and supplement use were assessed by use of a food frequency questionnaire. There were 876 incident BPH cases (33.6/1,000 person-years). The hazard ratios for the contrasts of the highest to lowest quintiles increased 31% for total fat and 27% for polyunsaturated fat and decreased 15% for protein (all ptrend < 0.05). The risk was significantly lower in high consumers of alcoholic beverages (0 vs. ≥2/day: hazard ratio (HR) = 0.67) and vegetables (<1 vs. ≥4/day: HR = 0.68) and higher in daily (vs. <1/week) consumers of red meat (HR = 1.38). There were no associations of supplemental antioxidants with risk, and there was weak evidence for associations of lycopene, zinc, and supplemental vitamin D with reduced risk. A diet low in fat and red meat and high in protein and vegetables, as well as regular alcohol consumption, may reduce the risk of symptomatic BPH.

AB - This study examined dietary risk factors for incident benign prostatic hyperplasia (BPH) in 4,770 Prostate Cancer Prevention Trial (1994-2003) placebo-arm participants who were free of BPH at baseline. BPH was assessed over 7 years and was defined as medical or surgical treatment or repeated elevation (>14) on the International Prostate Symptom Score questionnaire. Diet, alcohol, and supplement use were assessed by use of a food frequency questionnaire. There were 876 incident BPH cases (33.6/1,000 person-years). The hazard ratios for the contrasts of the highest to lowest quintiles increased 31% for total fat and 27% for polyunsaturated fat and decreased 15% for protein (all ptrend < 0.05). The risk was significantly lower in high consumers of alcoholic beverages (0 vs. ≥2/day: hazard ratio (HR) = 0.67) and vegetables (<1 vs. ≥4/day: HR = 0.68) and higher in daily (vs. <1/week) consumers of red meat (HR = 1.38). There were no associations of supplemental antioxidants with risk, and there was weak evidence for associations of lycopene, zinc, and supplemental vitamin D with reduced risk. A diet low in fat and red meat and high in protein and vegetables, as well as regular alcohol consumption, may reduce the risk of symptomatic BPH.

KW - Alcohol drinking

KW - Diet

KW - Dietary supplements

KW - Prostatic hyperplasia

UR - http://www.scopus.com/inward/record.url?scp=41649119115&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=41649119115&partnerID=8YFLogxK

U2 - 10.1093/aje/kwm389

DO - 10.1093/aje/kwm389

M3 - Article

C2 - 18263602

AN - SCOPUS:41649119115

VL - 167

SP - 925

EP - 934

JO - American Journal of Epidemiology

JF - American Journal of Epidemiology

SN - 0002-9262

IS - 8

ER -