Dietary modulation of the progression of nephropathy in aging rats: An evaluation of the importance of protein

E. J. Masoro, K. Iwasaki, C. A. Gleiser, C. A. McMahan, E. J. Seo, B. P. Yu

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Abstract

Chronic nephropathy involving glomerular sclerosis markedly progresses in severity with age in male Fischer 344 rats fed ad libitum. Restricting food intake by 40% almost totally prevents progression of these lesions. Restricting food intake by 40% without restricting protein intake is also highly effective although somewhat less so than food restriction that includes protein restriction. These findings indicate that reducing the intake of protein is not the major reason for the retardation by food restriction of the age-associated progression of nephropathy in rats.

Original languageEnglish (US)
Pages (from-to)1217-1227
Number of pages11
JournalAmerican Journal of Clinical Nutrition
Volume49
Issue number6
DOIs
StatePublished - Jan 1 1989

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ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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