Dietary glucarate-mediated reduction of sensitivity of murine strains to chemical carcinogenesis

Zbigniew Walaszek, Malgorzata Hanausek-Walaszek, Thomas E. Webb

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Serum β-glucuronidase activity is shown to differ quantitatively in the following strains of mice, listed in order of increasing activity: C3H, C57BL 6 < BALB c, DBA 2, ICR < SENCAR, A He. The level of the enzyme in the murine strains is shown to correlate with the urinary excretion of 17-ketosteroids, which in turn reflects the endogenous level of androgens. Dietary calcium d-glucarate, an in vivo β-glucuronidase inhibitor, reduced the steady state level of both β-glucuronidase and 17-ketosteroid excretion in the highly susceptible A He and SENCAR strains to that of strains known to be resistant to chemical carcinogenesis. Sensitivity of the A He strain is significantly reduced by dietary calcium glucarate, which is shown to inhibit DNA binding and the induction of pulmonary adenomas by benzo[a]pyrene.

Original languageEnglish (US)
Pages (from-to)25-32
Number of pages8
JournalCancer Letters
Volume33
Issue number1
DOIs
StatePublished - Oct 1986
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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