Dietary glucarate as anti-promoter of 7, 12-dimethylbenz[a]anthracene-induced mammary tumorigenesis

Zbigniew Walaszek, Malgorzata Hanausek-walaszek, John P. Minton, Thomas E. Webb

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

Using as a criterion the inhibition of serum β-glucuronidase activity, dietary calcium D-glucarate is shown to serve as an efficient slow-release source in vivo of D-glucaro-l, 4-lactone, the potent endogenous inhibitor of this enzyme. Using the 7, 12-dimethylbenz[a]anthracene model of mammary tumor induction in rats it is shown for the first time that feeding the rats calcium D-glucarate-supplemented diet after treatment with the carcinogen, inhibits tumor development by over 70%. Supportive evidence is presented for the theory that calcium D-glucarate inhibits or delays the promotion phase of mammary carcinogenesis by lowering endogenous levels of estradiol and precursors of 17-ketosteroids. Therefore, dietary glucarate can be used to lower blood and tissue levels of β-glucuronidase, and in turn of those carcinogens and promoting agents which are excreted, at least in part, as glucuronide conjugates.

Original languageEnglish (US)
Pages (from-to)1463-1466
Number of pages4
JournalCarcinogenesis
Volume7
Issue number9
DOIs
StatePublished - Sep 1986
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research

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