Dietary fish oil sensitizes A549 lung xenografts to doxorubicin chemotherapy

W. Elaine Hardman; Mary Pat Moyer; Ivan L. Cameron

doi:10.1016/S0304-3835(99)00396-1

Dietary fish oil sensitizes A549 lung xenografts to doxorubicin chemotherapy

W. Elaine Hardman, Mary Pat Moyer, Ivan L. Cameron

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

A549 xenografts were allowed to grow in nude mice to about 5 mm in diameter, then diets were changed to modified AIN-76 diets containing 19% wt./wt. fish oil (FO) or 20% wt./wt. corn oil (CO). Ten days later dietary ferric citrate (0.3% wt./dry wt.) was added and doxoribicin (DOX) treatment (3.6 mg/kg i.v. each of the 5 days for 18 days) commenced. Treatment with DOX halted the growth of tumors in the CO fed mice. However, in those mice, which consumed FO or FO with ferric citrate, treatment with DOX caused significant tumor regression. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original language	English (US)
Pages (from-to)	145-151
Number of pages	7
Journal	Cancer Letters
Volume	151
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3835(99)00396-1
State	Published - Apr 14 2000

Keywords

A549 lung cancers
Doxorubicin
Fish oil
Polyunsaturated fatty acids

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/S0304-3835(99)00396-1

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title = "Dietary fish oil sensitizes A549 lung xenografts to doxorubicin chemotherapy",

abstract = "A549 xenografts were allowed to grow in nude mice to about 5 mm in diameter, then diets were changed to modified AIN-76 diets containing 19% wt./wt. fish oil (FO) or 20% wt./wt. corn oil (CO). Ten days later dietary ferric citrate (0.3% wt./dry wt.) was added and doxoribicin (DOX) treatment (3.6 mg/kg i.v. each of the 5 days for 18 days) commenced. Treatment with DOX halted the growth of tumors in the CO fed mice. However, in those mice, which consumed FO or FO with ferric citrate, treatment with DOX caused significant tumor regression. Copyright (C) 2000 Elsevier Science Ireland Ltd.",

keywords = "A549 lung cancers, Doxorubicin, Fish oil, Polyunsaturated fatty acids",

author = "Hardman, {W. Elaine} and Moyer, {Mary Pat} and Cameron, {Ivan L.}",

note = "Funding Information: This research was supported by NCI grant 1R4176763-01 and by grants from the American Institute for Cancer Research and the Susan G. Komen Breast Cancer Foundation. ",

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T1 - Dietary fish oil sensitizes A549 lung xenografts to doxorubicin chemotherapy

AU - Hardman, W. Elaine

AU - Moyer, Mary Pat

AU - Cameron, Ivan L.

N1 - Funding Information: This research was supported by NCI grant 1R4176763-01 and by grants from the American Institute for Cancer Research and the Susan G. Komen Breast Cancer Foundation.

PY - 2000/4/14

Y1 - 2000/4/14

N2 - A549 xenografts were allowed to grow in nude mice to about 5 mm in diameter, then diets were changed to modified AIN-76 diets containing 19% wt./wt. fish oil (FO) or 20% wt./wt. corn oil (CO). Ten days later dietary ferric citrate (0.3% wt./dry wt.) was added and doxoribicin (DOX) treatment (3.6 mg/kg i.v. each of the 5 days for 18 days) commenced. Treatment with DOX halted the growth of tumors in the CO fed mice. However, in those mice, which consumed FO or FO with ferric citrate, treatment with DOX caused significant tumor regression. Copyright (C) 2000 Elsevier Science Ireland Ltd.

AB - A549 xenografts were allowed to grow in nude mice to about 5 mm in diameter, then diets were changed to modified AIN-76 diets containing 19% wt./wt. fish oil (FO) or 20% wt./wt. corn oil (CO). Ten days later dietary ferric citrate (0.3% wt./dry wt.) was added and doxoribicin (DOX) treatment (3.6 mg/kg i.v. each of the 5 days for 18 days) commenced. Treatment with DOX halted the growth of tumors in the CO fed mice. However, in those mice, which consumed FO or FO with ferric citrate, treatment with DOX caused significant tumor regression. Copyright (C) 2000 Elsevier Science Ireland Ltd.

KW - A549 lung cancers

KW - Doxorubicin

KW - Fish oil

KW - Polyunsaturated fatty acids

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Dietary fish oil sensitizes A549 lung xenografts to doxorubicin chemotherapy

Abstract

Keywords

ASJC Scopus subject areas

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