Dietary fish oil sensitizes A549 lung xenografts to doxorubicin chemotherapy

W. Elaine Hardman, Mary Pat Moyer, Ivan L. Cameron

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

A549 xenografts were allowed to grow in nude mice to about 5 mm in diameter, then diets were changed to modified AIN-76 diets containing 19% wt./wt. fish oil (FO) or 20% wt./wt. corn oil (CO). Ten days later dietary ferric citrate (0.3% wt./dry wt.) was added and doxoribicin (DOX) treatment (3.6 mg/kg i.v. each of the 5 days for 18 days) commenced. Treatment with DOX halted the growth of tumors in the CO fed mice. However, in those mice, which consumed FO or FO with ferric citrate, treatment with DOX caused significant tumor regression. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish (US)
Pages (from-to)145-151
Number of pages7
JournalCancer Letters
Volume151
Issue number2
DOIs
StatePublished - Apr 14 2000
Externally publishedYes

Keywords

  • A549 lung cancers
  • Doxorubicin
  • Fish oil
  • Polyunsaturated fatty acids

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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