Dietary coral calcium and zeolite protects bone in a mouse model for postmenopausal bone loss

Jameela Banu, Erika Varela, Juan M. Guerra, Ganesh Halade, Paul J. Williams, Ali N. Bahadur, Kokichi Hanaoka, Gabriel Fernandes

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

In patients diagnosed with osteoporosis, calcium is lost from bones making them weaker and easily susceptible to fractures. Supplementation of calcium is highly recommended for such conditions. However, the source of calcium plays an important role in the amount of calcium that is assimilated into bone. We hypothesize that naturally occurring coral calcium and zeolite may prevent ovariectomy-induced bone loss. We have measured bone loss in ovariectomized mice supplemented with coral calcium and Zeolite. Female C57BL/6 mice were either sham-operated or ovariectomized and fed diets containing coral calcium or zeolite for 6 months. Serum was analyzed for bone biochemical markers and cytokines. Bones were analyzed using dual x-ray absorbtiometry, peripheral quantitative computed tomography, and micro-computed tomography densitometry. In the distal femoral metaphysis, total bone and cortical bone mass was restored and the endocortical surface was significantly decreased in coral calcium and zeolite fed ovariectomized (OVX) mice. Trabecular number and the ratio of bone volume to total volume was higher in OVX mice after coral calcium and zeolite feeding, while trabecular separation decreased in the different treatment OVX groups. Coral calcium protected bone to a lesser extent in the proximal tibia and lumbar vertebrae. Overall, coral calcium and zeolite may protect postmenopausal bone loss.

Original languageEnglish (US)
Pages (from-to)965-975
Number of pages11
JournalNutrition Research
Volume32
Issue number12
DOIs
StatePublished - Dec 1 2012

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Keywords

  • C57BL/6 mice
  • Coral calcium
  • Densitometry
  • Mouse model of postmenopausal bone loss
  • Natural zeolite

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

Cite this

Banu, J., Varela, E., Guerra, J. M., Halade, G., Williams, P. J., Bahadur, A. N., Hanaoka, K., & Fernandes, G. (2012). Dietary coral calcium and zeolite protects bone in a mouse model for postmenopausal bone loss. Nutrition Research, 32(12), 965-975. https://doi.org/10.1016/j.nutres.2012.09.009