Diet modulates Th-1 and Th-2 cytokine production in the peripheral blood of lupus-prone mice

Christopher A. Jolly, Gabriel Fernandes

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Calorie restriction or fish oil extends life span. To investigate the potential mechanism(s) involved, young (4-month) and old (9-month) NZB x NZW(F1) mice were fed 5% (w/w) corn oil (CA) or fish oil (FA) ad libitum or 40% restricted (CR and FR, respectively). Peripheral blood T-lymphocytes were analyzed for Th-1 (IL-2, IFN-γ) and Th-2 (IL-5, IL-10) production. CR and FA partially blunted while FR completely abolished the decline in aged CD4+ T lymphocytes. In contrast, both CR and FR abolished the decline in CD8+ T lymphocytes with age, while FA had no effect. In aged mice, both CR and FR blunted the increase in Th-1 (IL-2, IFN-γ) cytokine production, while FA was only partially effective. Only FR completely blunted the age-related increase in Th-2 (IL-5, IL-10) cytokine production. These data suggest that FR delays the onset of autoimmune kidney disease by suppressing both Th-1 and Th-2 cytokine production.

Original languageEnglish (US)
Pages (from-to)172-178
Number of pages7
JournalJournal of Clinical Immunology
Volume19
Issue number3
DOIs
StatePublished - Jul 19 1999

Keywords

  • Diet
  • Lupus-prone mice
  • Peripheral blood
  • Th-1 cytokines
  • Th-2 cytokines

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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