Abstract
Background: The purpose of this study was to determine whether dietary manipulation can reliably induce early-stage atherosclerosis and clinically relevant changes in vascular function in an established, well-characterized non-human primate model. Methods: We fed 112 baboons a high-cholesterol, high-fat challenge diet for two years. We assayed circulating biomarkers of cardiovascular disease (CVD) risk, at 0, 7, and 104 weeks into the challenge; assessed arterial compliance noninvasively at 104 weeks; and measured atherosclerotic lesions in three major arteries at necropsy. Results: We observed evidence of atherosclerosis in all but one baboon fed the two-year challenge diet. CVD risk biomarkers, the prevalence, size, and complexity of arterial lesions, plus consequent arterial stiffness, were increased in comparison with dietary control animals. Conclusions: Feeding baboons a high-cholesterol, high-fat diet for two years reliably induces atherosclerosis, with risk factor profiles, arterial lesions, and changes in vascular function also seen in humans.
| Original language | English (US) |
|---|---|
| Journal | Journal of Medical Primatology |
| DOIs | |
| State | Accepted/In press - 2017 |
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Keywords
- Cardiovascular disease
- High-fat diet
- Non-human primate
ASJC Scopus subject areas
- Animal Science and Zoology
- veterinary(all)
Cite this
Diet-induced early-stage atherosclerosis in baboons : Lipoproteins, atherogenesis, and arterial compliance. / Mahaney, Michael C.; Karere, Genesio M.; Rainwater, David L.; Voruganti, Venkata S.; Dick, Edward J.; Owston, Michael A.; Rice, Karen S.; Cox, Laura A.; Comuzzie, Anthony G.; Vandeberg, John L.
In: Journal of Medical Primatology, 2017.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Diet-induced early-stage atherosclerosis in baboons
T2 - Lipoproteins, atherogenesis, and arterial compliance
AU - Mahaney, Michael C.
AU - Karere, Genesio M.
AU - Rainwater, David L.
AU - Voruganti, Venkata S.
AU - Dick, Edward J.
AU - Owston, Michael A.
AU - Rice, Karen S.
AU - Cox, Laura A.
AU - Comuzzie, Anthony G.
AU - Vandeberg, John L.
PY - 2017
Y1 - 2017
N2 - Background: The purpose of this study was to determine whether dietary manipulation can reliably induce early-stage atherosclerosis and clinically relevant changes in vascular function in an established, well-characterized non-human primate model. Methods: We fed 112 baboons a high-cholesterol, high-fat challenge diet for two years. We assayed circulating biomarkers of cardiovascular disease (CVD) risk, at 0, 7, and 104 weeks into the challenge; assessed arterial compliance noninvasively at 104 weeks; and measured atherosclerotic lesions in three major arteries at necropsy. Results: We observed evidence of atherosclerosis in all but one baboon fed the two-year challenge diet. CVD risk biomarkers, the prevalence, size, and complexity of arterial lesions, plus consequent arterial stiffness, were increased in comparison with dietary control animals. Conclusions: Feeding baboons a high-cholesterol, high-fat diet for two years reliably induces atherosclerosis, with risk factor profiles, arterial lesions, and changes in vascular function also seen in humans.
AB - Background: The purpose of this study was to determine whether dietary manipulation can reliably induce early-stage atherosclerosis and clinically relevant changes in vascular function in an established, well-characterized non-human primate model. Methods: We fed 112 baboons a high-cholesterol, high-fat challenge diet for two years. We assayed circulating biomarkers of cardiovascular disease (CVD) risk, at 0, 7, and 104 weeks into the challenge; assessed arterial compliance noninvasively at 104 weeks; and measured atherosclerotic lesions in three major arteries at necropsy. Results: We observed evidence of atherosclerosis in all but one baboon fed the two-year challenge diet. CVD risk biomarkers, the prevalence, size, and complexity of arterial lesions, plus consequent arterial stiffness, were increased in comparison with dietary control animals. Conclusions: Feeding baboons a high-cholesterol, high-fat diet for two years reliably induces atherosclerosis, with risk factor profiles, arterial lesions, and changes in vascular function also seen in humans.
KW - Cardiovascular disease
KW - High-fat diet
KW - Non-human primate
UR - http://www.scopus.com/inward/record.url?scp=85020545070&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85020545070&partnerID=8YFLogxK
U2 - 10.1111/jmp.12283
DO - 10.1111/jmp.12283
M3 - Article
AN - SCOPUS:85020545070
JO - Journal of Medical Primatology
JF - Journal of Medical Primatology
SN - 0047-2565
ER -