@article{35786cf955094d40917f9ae7c9ad8d35,
title = "Diet-induced early-stage atherosclerosis in baboons: Lipoproteins, atherogenesis, and arterial compliance",
abstract = "Background: The purpose of this study was to determine whether dietary manipulation can reliably induce early-stage atherosclerosis and clinically relevant changes in vascular function in an established, well-characterized non-human primate model. Methods: We fed 112 baboons a high-cholesterol, high-fat challenge diet for two years. We assayed circulating biomarkers of cardiovascular disease (CVD) risk, at 0, 7, and 104 weeks into the challenge; assessed arterial compliance noninvasively at 104 weeks; and measured atherosclerotic lesions in three major arteries at necropsy. Results: We observed evidence of atherosclerosis in all but one baboon fed the two-year challenge diet. CVD risk biomarkers, the prevalence, size, and complexity of arterial lesions, plus consequent arterial stiffness, were increased in comparison with dietary control animals. Conclusions: Feeding baboons a high-cholesterol, high-fat diet for two years reliably induces atherosclerosis, with risk factor profiles, arterial lesions, and changes in vascular function also seen in humans.",
keywords = "cardiovascular disease, high-fat diet, non-human primate",
author = "Mahaney, {Michael C.} and Karere, {Genesio M.} and Rainwater, {David L.} and Voruganti, {Venkata S.} and Dick, {Edward J.} and Owston, {Michael A.} and Rice, {Karen S.} and Cox, {Laura A.} and Comuzzie, {Anthony G.} and VandeBerg, {John L.}",
note = "Funding Information: Funding information Research reported in this manuscript was supported by a grant in aid from the National Institutes of Health (NIH): P01 HL028972. This investigation used resources, which were supported by the Southwest National Primate Research Center grant P51 RR013986 from the National Center for Research Resources, NIH, currently supported by the Office of Research Infrastructure Programs (ORIP), NIH through grant P51 OD011133. This investigation was conducted in facilities constructed with support from ORIP through grant numbers C06 RR14578, C06 RR15456, C06 RR013556, and C06 RR017515. The authors thank Wendy R Shelledy and Abel Moncivais for pulse wave analysis/pulse wave velocity data collection; Jesse C Martinez, Jacob E Martinez, and Samuel Galindo, for collection and preparation of arterial sections; Ahsan Choudary, Jennifer A. K. Harris, Shayna Levine, for processing and digital image analyses of arterial sections; Mari K. Hui, Perry H. Moore Jr., and Jane F. VandeBerg for assays of circulating biomarkers; Jim Bridges and Deborah E. Newman for data processing, management, and analytical programming support; Laura N. Tracey of PMI Nutrition International for valuable assistance with estimating the the composition of the atherogenic challenge diet; and the late Henry C. McGill, Jr., for valuable advice on assessment of atherosclerotic lesions in baboon arteries and pioneering contributions to the field which motivated much of the research reported in this paper. Funding Information: Research reported in this manuscript was supported by a grant in aid from the National Institutes of Health (NIH): P01 HL028972. This investigation used resources, which were supported by the Southwest National Primate Research Center grant P51 RR013986 from the National Center for Research Resources, NIH, currently supported by the Office of Research Infrastructure Programs (ORIP), NIH through grant P51 OD011133. This investigation was conducted in facilities constructed with support from ORIP through grant numbers C06 RR14578, C06 RR15456, C06 RR013556, and C06 RR017515. Publisher Copyright: {\textcopyright} 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd",
year = "2018",
month = feb,
day = "1",
doi = "10.1111/jmp.12283",
language = "English (US)",
volume = "47",
pages = "3--17",
journal = "Journal of Medical Primatology",
issn = "0047-2565",
publisher = "Blackwell Munksgaard",
number = "1",
}