Diet-induced early-stage atherosclerosis in baboons: Lipoproteins, atherogenesis, and arterial compliance

Michael C. Mahaney; Genesio M. Karere; David L. Rainwater; Venkata S. Voruganti; Edward J. Dick; Michael A. Owston; Karen S. Rice; Laura A. Cox; Anthony G. Comuzzie; John L. VandeBerg

doi:10.1111/jmp.12283

Diet-induced early-stage atherosclerosis in baboons: Lipoproteins, atherogenesis, and arterial compliance

Michael C. Mahaney, Genesio M. Karere, David L. Rainwater, Venkata S. Voruganti, Edward J. Dick, Michael A. Owston, Karen S. Rice, Laura A. Cox, Anthony G. Comuzzie, John L. VandeBerg

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Background: The purpose of this study was to determine whether dietary manipulation can reliably induce early-stage atherosclerosis and clinically relevant changes in vascular function in an established, well-characterized non-human primate model. Methods: We fed 112 baboons a high-cholesterol, high-fat challenge diet for two years. We assayed circulating biomarkers of cardiovascular disease (CVD) risk, at 0, 7, and 104 weeks into the challenge; assessed arterial compliance noninvasively at 104 weeks; and measured atherosclerotic lesions in three major arteries at necropsy. Results: We observed evidence of atherosclerosis in all but one baboon fed the two-year challenge diet. CVD risk biomarkers, the prevalence, size, and complexity of arterial lesions, plus consequent arterial stiffness, were increased in comparison with dietary control animals. Conclusions: Feeding baboons a high-cholesterol, high-fat diet for two years reliably induces atherosclerosis, with risk factor profiles, arterial lesions, and changes in vascular function also seen in humans.

Original language	English (US)
Pages (from-to)	3-17
Number of pages	15
Journal	Journal of medical primatology
Volume	47
Issue number	1
DOIs	https://doi.org/10.1111/jmp.12283
State	Published - Feb 1 2018

Keywords

cardiovascular disease
high-fat diet
non-human primate

ASJC Scopus subject areas

Animal Science and Zoology
veterinary(all)

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10.1111/jmp.12283

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Diet-induced early-stage atherosclerosis in baboons : Lipoproteins, atherogenesis, and arterial compliance. / Mahaney, Michael C.; Karere, Genesio M.; Rainwater, David L.; Voruganti, Venkata S.; Dick, Edward J.; Owston, Michael A.; Rice, Karen S.; Cox, Laura A.; Comuzzie, Anthony G.; VandeBerg, John L.

In: Journal of medical primatology, Vol. 47, No. 1, 01.02.2018, p. 3-17.

Research output: Contribution to journal › Article › peer-review

Mahaney, Michael C. ; Karere, Genesio M. ; Rainwater, David L. ; Voruganti, Venkata S. ; Dick, Edward J. ; Owston, Michael A. ; Rice, Karen S. ; Cox, Laura A. ; Comuzzie, Anthony G. ; VandeBerg, John L. / Diet-induced early-stage atherosclerosis in baboons : Lipoproteins, atherogenesis, and arterial compliance. In: Journal of medical primatology. 2018 ; Vol. 47, No. 1. pp. 3-17.

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title = "Diet-induced early-stage atherosclerosis in baboons: Lipoproteins, atherogenesis, and arterial compliance",

abstract = "Background: The purpose of this study was to determine whether dietary manipulation can reliably induce early-stage atherosclerosis and clinically relevant changes in vascular function in an established, well-characterized non-human primate model. Methods: We fed 112 baboons a high-cholesterol, high-fat challenge diet for two years. We assayed circulating biomarkers of cardiovascular disease (CVD) risk, at 0, 7, and 104 weeks into the challenge; assessed arterial compliance noninvasively at 104 weeks; and measured atherosclerotic lesions in three major arteries at necropsy. Results: We observed evidence of atherosclerosis in all but one baboon fed the two-year challenge diet. CVD risk biomarkers, the prevalence, size, and complexity of arterial lesions, plus consequent arterial stiffness, were increased in comparison with dietary control animals. Conclusions: Feeding baboons a high-cholesterol, high-fat diet for two years reliably induces atherosclerosis, with risk factor profiles, arterial lesions, and changes in vascular function also seen in humans.",

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note = "Funding Information: Research reported in this manuscript was supported by a grant in aid from the National Institutes of Health (NIH): P01 HL028972. This investigation used resources, which were supported by the Southwest National Primate Research Center grant P51 RR013986 from the National Center for Research Resources, NIH, currently supported by the Office of Research Infrastructure Programs (ORIP), NIH through grant P51 OD011133. This investigation was conducted in facilities constructed with support from ORIP through grant numbers C06 RR14578, C06 RR15456, C06 RR013556, and C06 RR017515.",

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AU - Rainwater, David L.

AU - Voruganti, Venkata S.

AU - Dick, Edward J.

AU - Owston, Michael A.

AU - Rice, Karen S.

AU - Cox, Laura A.

AU - Comuzzie, Anthony G.

AU - VandeBerg, John L.

N1 - Funding Information: Research reported in this manuscript was supported by a grant in aid from the National Institutes of Health (NIH): P01 HL028972. This investigation used resources, which were supported by the Southwest National Primate Research Center grant P51 RR013986 from the National Center for Research Resources, NIH, currently supported by the Office of Research Infrastructure Programs (ORIP), NIH through grant P51 OD011133. This investigation was conducted in facilities constructed with support from ORIP through grant numbers C06 RR14578, C06 RR15456, C06 RR013556, and C06 RR017515.

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N2 - Background: The purpose of this study was to determine whether dietary manipulation can reliably induce early-stage atherosclerosis and clinically relevant changes in vascular function in an established, well-characterized non-human primate model. Methods: We fed 112 baboons a high-cholesterol, high-fat challenge diet for two years. We assayed circulating biomarkers of cardiovascular disease (CVD) risk, at 0, 7, and 104 weeks into the challenge; assessed arterial compliance noninvasively at 104 weeks; and measured atherosclerotic lesions in three major arteries at necropsy. Results: We observed evidence of atherosclerosis in all but one baboon fed the two-year challenge diet. CVD risk biomarkers, the prevalence, size, and complexity of arterial lesions, plus consequent arterial stiffness, were increased in comparison with dietary control animals. Conclusions: Feeding baboons a high-cholesterol, high-fat diet for two years reliably induces atherosclerosis, with risk factor profiles, arterial lesions, and changes in vascular function also seen in humans.

AB - Background: The purpose of this study was to determine whether dietary manipulation can reliably induce early-stage atherosclerosis and clinically relevant changes in vascular function in an established, well-characterized non-human primate model. Methods: We fed 112 baboons a high-cholesterol, high-fat challenge diet for two years. We assayed circulating biomarkers of cardiovascular disease (CVD) risk, at 0, 7, and 104 weeks into the challenge; assessed arterial compliance noninvasively at 104 weeks; and measured atherosclerotic lesions in three major arteries at necropsy. Results: We observed evidence of atherosclerosis in all but one baboon fed the two-year challenge diet. CVD risk biomarkers, the prevalence, size, and complexity of arterial lesions, plus consequent arterial stiffness, were increased in comparison with dietary control animals. Conclusions: Feeding baboons a high-cholesterol, high-fat diet for two years reliably induces atherosclerosis, with risk factor profiles, arterial lesions, and changes in vascular function also seen in humans.

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