TY - JOUR
T1 - Diet, individual responsiveness and cancer prevention
AU - Wargovich, Michael J.
AU - Cunningham, Joan E.
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2003/7/1
Y1 - 2003/7/1
N2 - Dietary recommendations for the prevention of cancer have been based predominantly on large epidemiological studies of diet and lifestyle, conducted 20, and in some cases, almost 30 years ago. Government programs have been successful in educating the public about the benefits of eating fruits and vegetables, yet despite these efforts, Americans have become heavier, diabetes is more prevalent and general health indicators have not greatly improved. Individual response to dietary recommendations may be complicated by a variety of factors. Polymorphisms in genes related to drug activation and detoxification, folate metabolism, DNA repair, vitamin receptors and other cellular receptors could account for a lack of benefit at the level of the individual for consuming cancer preventive foods. Beyond consideration of genetic polymorphisms, the last half century has brought stark changes in lifestyle that depart from normal diurnal cycle and periodic fluctuations in food availability. Thus, modern times may be characterized as being constantly in a "feast" environment. The cellular consequences may be an increase in risk for several diseases including cancer.
AB - Dietary recommendations for the prevention of cancer have been based predominantly on large epidemiological studies of diet and lifestyle, conducted 20, and in some cases, almost 30 years ago. Government programs have been successful in educating the public about the benefits of eating fruits and vegetables, yet despite these efforts, Americans have become heavier, diabetes is more prevalent and general health indicators have not greatly improved. Individual response to dietary recommendations may be complicated by a variety of factors. Polymorphisms in genes related to drug activation and detoxification, folate metabolism, DNA repair, vitamin receptors and other cellular receptors could account for a lack of benefit at the level of the individual for consuming cancer preventive foods. Beyond consideration of genetic polymorphisms, the last half century has brought stark changes in lifestyle that depart from normal diurnal cycle and periodic fluctuations in food availability. Thus, modern times may be characterized as being constantly in a "feast" environment. The cellular consequences may be an increase in risk for several diseases including cancer.
KW - Cancer
KW - Diet
KW - Feast and famine
KW - Polymorphisms
KW - Thrifty gene
UR - http://www.scopus.com/inward/record.url?scp=0038338885&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0038338885&partnerID=8YFLogxK
U2 - 10.1093/jn/133.7.2400s
DO - 10.1093/jn/133.7.2400s
M3 - Article
C2 - 12840215
AN - SCOPUS:0038338885
VL - 133
SP - 2400S-2403S
JO - Journal of Nutrition
JF - Journal of Nutrition
SN - 0022-3166
IS - 7 SUPPL.
ER -