Did TCDD exposure or service in Southeast Asia increase the risk of cancer in air force Vietnam veterans who did not spray agent orange?

Marian Pavuk, Joel E. Michalek, Arnold Schecter, Norma S. Ketchum, Fatema Z. Akhtar, Karen A. Fox

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Objective: We sought to examine cancer incidence in 1482 Air Force veterans who served in Southeast Asia (SEA) and who were not occupationally exposed to herbicides. Methods: Cancer incidence between 1982 and 2003 was determined by record review and Cox proportional hazards models were used to estimate risk ratios across serum 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and years served in SEA categories. Results: All sites cancer risk increased with TCDD (relative risk = 1.6, 95% confidence interval = 1.2-2.2). The risk of prostate cancer increased with years of SEA service but not with TCDD. TCDD and years of SEA service interacted with all sites cancer; the risk was greatest in those with the highest TCDD levels and the longest time served in SEA. Conclusions: These results suggest nonoccupational exposures to TCDD or other factors while in SEA may contribute to cancer risk in these veterans.

Original languageEnglish (US)
Pages (from-to)335-342
Number of pages8
JournalJournal of Occupational and Environmental Medicine
Volume47
Issue number4
DOIs
StatePublished - Apr 2005

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Southeastern Asia
Vietnam
Veterans
Air
Neoplasms
Incidence
Herbicides
Proportional Hazards Models
Agent Orange
Polychlorinated Dibenzodioxins
Prostatic Neoplasms
Odds Ratio
Confidence Intervals
Serum

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

Did TCDD exposure or service in Southeast Asia increase the risk of cancer in air force Vietnam veterans who did not spray agent orange? / Pavuk, Marian; Michalek, Joel E.; Schecter, Arnold; Ketchum, Norma S.; Akhtar, Fatema Z.; Fox, Karen A.

In: Journal of Occupational and Environmental Medicine, Vol. 47, No. 4, 04.2005, p. 335-342.

Research output: Contribution to journalArticle

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