Abstract
Objective: We sought to examine cancer incidence in 1482 Air Force veterans who served in Southeast Asia (SEA) and who were not occupationally exposed to herbicides. Methods: Cancer incidence between 1982 and 2003 was determined by record review and Cox proportional hazards models were used to estimate risk ratios across serum 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and years served in SEA categories. Results: All sites cancer risk increased with TCDD (relative risk = 1.6, 95% confidence interval = 1.2-2.2). The risk of prostate cancer increased with years of SEA service but not with TCDD. TCDD and years of SEA service interacted with all sites cancer; the risk was greatest in those with the highest TCDD levels and the longest time served in SEA. Conclusions: These results suggest nonoccupational exposures to TCDD or other factors while in SEA may contribute to cancer risk in these veterans.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 335-342 |
| Number of pages | 8 |
| Journal | Journal of Occupational and Environmental Medicine |
| Volume | 47 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 2005 |
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ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Health, Toxicology and Mutagenesis
Cite this
Did TCDD exposure or service in Southeast Asia increase the risk of cancer in air force Vietnam veterans who did not spray agent orange? / Pavuk, Marian; Michalek, Joel E.; Schecter, Arnold; Ketchum, Norma S.; Akhtar, Fatema Z.; Fox, Karen A.
In: Journal of Occupational and Environmental Medicine, Vol. 47, No. 4, 04.2005, p. 335-342.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Did TCDD exposure or service in Southeast Asia increase the risk of cancer in air force Vietnam veterans who did not spray agent orange?
AU - Pavuk, Marian
AU - Michalek, Joel E.
AU - Schecter, Arnold
AU - Ketchum, Norma S.
AU - Akhtar, Fatema Z.
AU - Fox, Karen A.
PY - 2005/4
Y1 - 2005/4
N2 - Objective: We sought to examine cancer incidence in 1482 Air Force veterans who served in Southeast Asia (SEA) and who were not occupationally exposed to herbicides. Methods: Cancer incidence between 1982 and 2003 was determined by record review and Cox proportional hazards models were used to estimate risk ratios across serum 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and years served in SEA categories. Results: All sites cancer risk increased with TCDD (relative risk = 1.6, 95% confidence interval = 1.2-2.2). The risk of prostate cancer increased with years of SEA service but not with TCDD. TCDD and years of SEA service interacted with all sites cancer; the risk was greatest in those with the highest TCDD levels and the longest time served in SEA. Conclusions: These results suggest nonoccupational exposures to TCDD or other factors while in SEA may contribute to cancer risk in these veterans.
AB - Objective: We sought to examine cancer incidence in 1482 Air Force veterans who served in Southeast Asia (SEA) and who were not occupationally exposed to herbicides. Methods: Cancer incidence between 1982 and 2003 was determined by record review and Cox proportional hazards models were used to estimate risk ratios across serum 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and years served in SEA categories. Results: All sites cancer risk increased with TCDD (relative risk = 1.6, 95% confidence interval = 1.2-2.2). The risk of prostate cancer increased with years of SEA service but not with TCDD. TCDD and years of SEA service interacted with all sites cancer; the risk was greatest in those with the highest TCDD levels and the longest time served in SEA. Conclusions: These results suggest nonoccupational exposures to TCDD or other factors while in SEA may contribute to cancer risk in these veterans.
UR - http://www.scopus.com/inward/record.url?scp=17144402179&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=17144402179&partnerID=8YFLogxK
U2 - 10.1097/01.jom.0000158739.56427.24
DO - 10.1097/01.jom.0000158739.56427.24
M3 - Article
C2 - 15824624
AN - SCOPUS:17144402179
VL - 47
SP - 335
EP - 342
JO - Journal of Occupational and Environmental Medicine
JF - Journal of Occupational and Environmental Medicine
SN - 1076-2752
IS - 4
ER -