Dichlorvos and the cholinergic system: effects on cholinesterase and acetylcholine and choline contents of rat tissues

A. T. Modak, W. B. Stavinoha, S. T. Weintraub

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

The inhibition of cholinesterase by 50 mg/kg/5 ml, p.o., dichlorvos and subsequent recovery of enzyme activity was uniform in all brain regions studied. This uniformity was not observed in liver, erythrocytes and plasma. Acetylcholine levels were elevated in brain areas from 48 to 171% at 15 minutes after treatment. However, a biphasic effect was seen on choline metabolism in the brain. The cortex was found to be more cholinergic than the striatum in terms of per cent increase in acetylcholine and choline.

Original languageEnglish (US)
Pages (from-to)293-301
Number of pages9
JournalArchives internationales de pharmacodynamie et de therapie
Volume217
Issue number2
StatePublished - Dec 1 1975

ASJC Scopus subject areas

  • Pharmacology

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