Diazepam inhibition of phorbol ester tumor promotion

Susan M. Fischer, Leroy G. Hardin, Thomas J. Slaga

Research output: Contribution to journalArticle

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Abstract

Diazepam (Valium) had previously been shown to enhance the growth rate of some transplantable tumors although studies in other systems have suggested an inhibitory effect. Skin tumor promotion studies were therefore carried out to determine the effect of diazepam on 12-O-tetradecanoyl phorbol-13-acetate (TPA) promotion in SENCAR mice. A sex-independent dose response inhibition occurred over a dose range of 100 g to 5 mg, both in number of papillomas and percent of mice bearing tumors. Furthermore, a dose-response reduction in tumor size was observed. By itself, diazepam had no tumor promoting activity.

Original languageEnglish (US)
Pages (from-to)181-187
Number of pages7
JournalCancer Letters
Volume19
Issue number2
DOIs
Publication statusPublished - Jun 1983

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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