Diallylsulfide and allylmethylsulfide are uniquely effective among organosulfur compounds in inhibiting CYP2E1 protein in animal models

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41 Citations (Scopus)

Abstract

Garlic is a popular culinary herb that is also used throughout the world as a traditional medicine for the prevention and treatment of disease. Epidemiologic studies have suggested that long-term consumption of garlic reduces risk for certain cancers, most notably stomach and colon cancer. This article summarizes the key findings behind one important mechanism explaining the anticarcinogenic effects of garlic-derived agents in animal models: the inhibition of cytochrome p4502E1 (CYP2E1), with some commentary on other aspects of carcinogen metabolism modified by these unique phytochemicals.

Original languageEnglish (US)
JournalJournal of Nutrition
Volume136
Issue number3
StatePublished - Mar 2006
Externally publishedYes

Fingerprint

organic sulfur compounds
Garlic
Cytochromes
cytochromes
garlic
Animal Models
animal models
Anticarcinogenic Agents
Proteins
stomach neoplasms
proteins
Phytochemicals
Traditional Medicine
anticarcinogenic activity
carcinogens
traditional medicine
colorectal neoplasms
Carcinogens
Colonic Neoplasms
epidemiological studies

Keywords

  • Carcinogenesis
  • Chemoprevention
  • Colon cancer
  • CYP2E12e1
  • Garlic

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

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AB - Garlic is a popular culinary herb that is also used throughout the world as a traditional medicine for the prevention and treatment of disease. Epidemiologic studies have suggested that long-term consumption of garlic reduces risk for certain cancers, most notably stomach and colon cancer. This article summarizes the key findings behind one important mechanism explaining the anticarcinogenic effects of garlic-derived agents in animal models: the inhibition of cytochrome p4502E1 (CYP2E1), with some commentary on other aspects of carcinogen metabolism modified by these unique phytochemicals.

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