Abstract
Diallyl sulfide, a thioether found naturally in garlic, when given by gavage to C57BL/6J mice inhibited by 74% the incidence and reduced the frequency of colorectal adeno carcinoma induced by 20 weekly injections of 1,2-dimethyl-hydrazine. This result was predicted from a short-term assay measuring defects in nuclear morphology in mouse colon epithelial cells. This chemical is representative of a class of naturally occurring sulfur compounds with profound phar macologic activity, one aspect of which may be cancer prevention.
Original language | English (US) |
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Pages (from-to) | 487-489 |
Number of pages | 3 |
Journal | Carcinogenesis |
Volume | 8 |
Issue number | 3 |
DOIs | |
State | Published - Mar 1987 |
Externally published | Yes |
ASJC Scopus subject areas
- Cancer Research