Diallyl sulfide, a flavor component of garlic (allium sativum), inhibits dimethyihydrazine-induced colon cancer

Michael J. Wargovich

doi:10.1093/carcin/8.3.487

Diallyl sulfide, a flavor component of garlic (allium sativum), inhibits dimethyihydrazine-induced colon cancer

Michael J. Wargovich

Research output: Contribution to journal › Article › peer-review

276 Scopus citations

Abstract

Diallyl sulfide, a thioether found naturally in garlic, when given by gavage to C57BL/6J mice inhibited by 74% the incidence and reduced the frequency of colorectal adeno carcinoma induced by 20 weekly injections of 1,2-dimethyl-hydrazine. This result was predicted from a short-term assay measuring defects in nuclear morphology in mouse colon epithelial cells. This chemical is representative of a class of naturally occurring sulfur compounds with profound phar macologic activity, one aspect of which may be cancer prevention.

Original language	English (US)
Pages (from-to)	487-489
Number of pages	3
Journal	Carcinogenesis
Volume	8
Issue number	3
DOIs	https://doi.org/10.1093/carcin/8.3.487
State	Published - Mar 1987
Externally published	Yes

ASJC Scopus subject areas

Cancer Research

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10.1093/carcin/8.3.487

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title = "Diallyl sulfide, a flavor component of garlic (allium sativum), inhibits dimethyihydrazine-induced colon cancer",

abstract = "Diallyl sulfide, a thioether found naturally in garlic, when given by gavage to C57BL/6J mice inhibited by 74% the incidence and reduced the frequency of colorectal adeno carcinoma induced by 20 weekly injections of 1,2-dimethyl-hydrazine. This result was predicted from a short-term assay measuring defects in nuclear morphology in mouse colon epithelial cells. This chemical is representative of a class of naturally occurring sulfur compounds with profound phar macologic activity, one aspect of which may be cancer prevention.",

author = "Wargovich, {Michael J.}",

note = "Funding Information: I thank C.Woods, T.Benke, F.Lointier and M.Goodstein for their excellent technical assistance and L.C.Stephens for the pathologic analysis; I also thank B.Levin and L.Wildrick for their editorial assistance on earlier drafts. Supported by grants from the Elsa U.Pardee Foundation, the University of Texas System Cancer Center, and NCI Cancer Center Support Grant (CA-16672).",

year = "1987",

month = mar,

doi = "10.1093/carcin/8.3.487",

language = "English (US)",

volume = "8",

pages = "487--489",

journal = "Carcinogenesis",

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T1 - Diallyl sulfide, a flavor component of garlic (allium sativum), inhibits dimethyihydrazine-induced colon cancer

AU - Wargovich, Michael J.

N1 - Funding Information: I thank C.Woods, T.Benke, F.Lointier and M.Goodstein for their excellent technical assistance and L.C.Stephens for the pathologic analysis; I also thank B.Levin and L.Wildrick for their editorial assistance on earlier drafts. Supported by grants from the Elsa U.Pardee Foundation, the University of Texas System Cancer Center, and NCI Cancer Center Support Grant (CA-16672).

PY - 1987/3

Y1 - 1987/3

N2 - Diallyl sulfide, a thioether found naturally in garlic, when given by gavage to C57BL/6J mice inhibited by 74% the incidence and reduced the frequency of colorectal adeno carcinoma induced by 20 weekly injections of 1,2-dimethyl-hydrazine. This result was predicted from a short-term assay measuring defects in nuclear morphology in mouse colon epithelial cells. This chemical is representative of a class of naturally occurring sulfur compounds with profound phar macologic activity, one aspect of which may be cancer prevention.

AB - Diallyl sulfide, a thioether found naturally in garlic, when given by gavage to C57BL/6J mice inhibited by 74% the incidence and reduced the frequency of colorectal adeno carcinoma induced by 20 weekly injections of 1,2-dimethyl-hydrazine. This result was predicted from a short-term assay measuring defects in nuclear morphology in mouse colon epithelial cells. This chemical is representative of a class of naturally occurring sulfur compounds with profound phar macologic activity, one aspect of which may be cancer prevention.

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Diallyl sulfide, a flavor component of garlic (allium sativum), inhibits dimethyihydrazine-induced colon cancer

Abstract

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