Diallyl sulfide, a flavor component of garlic (allium sativum), inhibits dimethyihydrazine-induced colon cancer

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Abstract

Diallyl sulfide, a thioether found naturally in garlic, when given by gavage to C57BL/6J mice inhibited by 74% the incidence and reduced the frequency of colorectal adeno carcinoma induced by 20 weekly injections of 1,2-dimethyl-hydrazine. This result was predicted from a short-term assay measuring defects in nuclear morphology in mouse colon epithelial cells. This chemical is representative of a class of naturally occurring sulfur compounds with profound phar macologic activity, one aspect of which may be cancer prevention.

Original languageEnglish (US)
Pages (from-to)487-489
Number of pages3
JournalCarcinogenesis
Volume8
Issue number3
DOIs
StatePublished - Mar 1987
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research

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